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Research Associate II, Histotechnician

Frederick National Laboratory for Cancer Research
Frederick, MD
Start date
Sep 13, 2022

View more

Regulatory, Research/Documentation, Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Research Associate II, Histotechnician

Job ID: req2956
Employee Type: exempt full-time
Division: Clinical Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.


The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research’s Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha is charged with the development and application of genomic assays for use in medical research and diagnostics for DCTD-sponsored national extramural clinical trials. The MoCha Histology lab supports these efforts by performing all pre-analytic histological needs prior to genomic analysis.


The Research Associate II (RA II) will assist with the operation of the CLIA‐certified MoCha Histology laboratory aimed at the evaluation of xenograft mouse models, in vitro cell culture models, and clinical samples by performing routine histology procedures such as sample accessioning, trimming, and processing. The RA II will also perform paraffin block sectioning, flash frozen (FF) tissue sectioning, H&E staining, whole slide imaging, and develop and run IF/IHC assays specific for routine samples and experiment project samples.

  • Perform histology procedures to include but not limited to tissue trimming, processing, embedding, microtomy, H&E staining, IF/IHC staining, and whole slide imaging.
  • Assist in development and implementation of new immunofluorescence/immunohistochemistry assays.
  • Support the development of spatial profiling assays.
  • Evaluate suitability and quality control of research or production assays or tests, develop SOPs, and analyze and report results.
  • Organize, maintain, and track information of large cohorts of samples.
  • Monitor progress of multiple projects.
  • Maintain daily lab records, follow SOPs, and adhere to all laboratory safety guidelines.
  • Maintain essential laboratory supplies and monitors equipment for optimum performance.
  • This position will be located in Frederick, Maryland.


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of Bachelor’s degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the education requirement, a minimum of five (5) years of progressively responsible experience.
  • Experience in histology and IF/IHC assays.
  • Ability to maintain accurate and detailed records.
  • Work effectively in a team‐oriented environment.
  • Ability to evaluate the suitability and quality control of research or production assays or tests, develop and follow SOPs, and analyze and report results.
  • Adequate computer skills to document, organize, and present experimental data.
  • Strong critical thinking and problem-solving skills.
  • Ability to communicate effectively both verbally and in writing.
  • Ability to obtain and maintain a security clearance.


Candidates with these desired skills will be given preferential consideration:  

  • Strong technical skills in IF/IHC assay development.
  • Knowledge of basic histology skills and techniques.
  • Familiarity with regulatory guidelines (i.e. CLIA, CAP, GLP).
  • Highly motivated with a desire to learn new technologies.


  • This position is subject to working with or have potential for exposure to animal(s)
    and/or animal material(s).
  • This position is subject to working with or have potential for exposure to infectious
    material, requiring medical clearance and immunizations.
  • This position may require continuous or intermittent exposure to and exertion in
    environmental conditions such as working outdoors, temperature extremes, humidity extremes.
    etc. as part of the job.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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