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Associate Director, Structural Biology and Biochemistry

Global Blood Therapeutics
South San Francisco, CA
Start date
Sep 11, 2022

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Science/R&D, Biology
Required Education
Position Type
Full time
Biotech Bay
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Job Details


Position Summary:

Global Blood Therapeutics, Inc. (GBT) is seeking an Associate Director with expertise in structural biology and protein biochemistry, and a passion to understand mechanisms of disease and treatment. The successful candidate will join a multi-disciplinary team and support our drug discovery effort by investigating protein crystallography and SAR of drug candidates to elucidate the drug mechanisms of action on the target. He or She will lead the structural biology function and be a key member in multiple drug discovery projects. Major responsibilities will include technology development, providing critical input on structure-based drug design, and novel biochemical assay development to translate SAR insight into testable hypotheses. The ideal candidate will be highly motivated, detail-oriented, working independently with a variety of technologies to interrogate protein structure, biophysical and biochemical properties of protein and drug interactions, and be the SME in cross-functional teams.

Essential Duties and Responsibilities:

  • Build and manage the Structural Biology and Biochemistry function in Research
  • Design, enable, and execute Structural Biology and Biochemistry strategies across GBT’s pipeline programs and projects
  • Partner with Research teams to advance GBT’s drug discovery projects and portfolio
  • Foster collaboration and partnership with interdisciplinary members in Research teams
  • Initiate and lead external strategic collaborations and CRO resources to broaden the capabilities and improve operational efficiency and flexibility
  • Lead and contribute to scientific presentations and publications internally and externally at scientific conferences
  • Keep up to date on scientific advancements and new technologies


  • PhD in Structural Biology, Biochemistry, Biophysics or a related field
  • 7+ years of industry experience in drug discovery
  • 3+ years of experience in leading and managing high performing teams/groups
  • Demonstrated ability of delivering structures and using structure-based drug design for hit identification, lead generation and optimization
  • Experience in biochemical assay development to interrogate drug MOA
  • Experience in leading and managing early discovery projects
  • Strong record of publications, patents, and project achievements
  • Experience in managing scientific collaborations and CRO outsourcing activities
  • Experience in scientific programming (Shell scripting, Python, Perl) and working with state-of-the-art software packages is a plus
  • Experience with cloud-based IT infrastructure is a plus
  • Excellent written and oral communication skills

Fit with GBT culture:

  • Ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Values-based leadership consistent with GBT's Core Values
  • Excitement about the vision and mission of GBT
  • Flexibility
  • Integrity

NOTE:  This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities.  The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.



Global Blood Therapeutics (GBT) is a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. Founded in 2011, GBT is delivering on its goal to transform the treatment and care of sickle cell disease (SCD), a lifelong, devastating inherited blood disorder. The company has introduced Oxbryta® (voxelotor), the first FDA-approved treatment that directly inhibits sickle hemoglobin polymerization, the root cause of SCD. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. In addition, GBT’s drug discovery teams are working on new targets to develop the next generation of treatments for SCD. To learn more, please visit and follow the company on Twitter @GBT_news.

Find Us
181 Oyster Point Blvd
South San Francisco
United States
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