Associate Scientist I/ II
- Employer
- AbbVie
- Location
- Worcester, Massachusetts
- Start date
- Sep 9, 2022
View more
- Discipline
- Science/R&D, Biotechnology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Genetown, Best Places to Work
Job Details
AbbVie Inc is embracing new paradigms and technologies to develop novel and life-changing therapies for cancer. We are seeking a highly motivated and energetic teammate to operate in a LC/MS-based quantitative bioanalytical role to support research and development projects.
The LC/MS bioanalytical team is looking for an experienced Bioanalytical Scientist to assist in qualitative and quantitative bioanalysis of large molecules to support drug discovery and early development projects at AbbVie. The ideal candidate will be experienced in the optimization and implementation of novel and routine LC/MS-based bioanalytical methods to drive in-vivo PK, TK, and PK/PD as well as in-vitro stability characterization of large molecules. The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, writing reports, and presenting data at internal meetings.
Key tasks and responsibilities:
- Optimize and implement bioanalytical methods for identifying and quantifying antibody and antibody drug conjugates, proteins, peptides, and small molecules using LC-MS/MS.
- Routinely operate LC/MS and automation instrumentation, including maintenance and troubleshooting.
- Expert in immunoaffinity capture LCMS using automation for biologics stability evaluations.
- Continuously improve bioanalytical workflows efficiency and ensure laboratory capacity meets project demand. Writes and maintains Protocol and facilitate assay optimization and implementation to ensure data quality.
- Communicate data interpretation to DMPK colleagues and project teams
- Utilize and maintain electronic laboratory notebooks for study documentation
Education and Experience:
- Degree in chemistry, biochemistry, pharmacology or other related field. BS with 3 years or MS with no experience in a pharmaceutical industry setting.
- Highly motivated individual with a strong intellectual and technical background in preclinical DMPK and bioanalytical methods, specifically large molecule LC-MS/MS. Expertise in qualitative LC-MS analysis of large molecules.
- Deep and broad knowledge in analytical science and applied technologies. Direct hands-on experience and strong trouble shooting skills in LC/MS bioanalytical laboratory (High end QTOF MS, Triple quad MS, and automation).
- Knowledge in drug discovery and related disciplines. In-depth understanding of in-vitro assays as well as in vivo PK, tox studies and corresponding bioanalytical assays. Demonstrated ability to manage and analyze data using advanced software tools.
- Excellent verbal and written communications skills and ability to work independently and excel in a team environment.
- Strong analytical, organizational, and interpersonal skills.
- Desire to excel in a fast-paced environment
Company
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.
Stock Symbol: ABBV
Stock Exchange: NYSE
- Website
- http://www.abbvie.com/
- Phone
- 1-800-255-5162
- Location
-
1 North Waukegan Road
North Chicago
Illinois
60064
US
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