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Scientist, Immunosuppression (non- PhD)

Employer
Pfizer
Location
La Jolla, California
Start date
Sep 9, 2022

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Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Beach, Best Places to Work
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Job Details

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire a scientist for the CID Immunosuppression group. This role is predominantly laboratory-based (~80% of time) with a major emphasis placed upon implementing state-of-the-art immunologic techniques and routinely conducting high-quality assay work in an organized and safe manner. Primary responsibilities will include designing and implementing assay readout work plans, performing and overseeing cell-based immune readouts, profiling cell populations using flow cytometry, performing immunohistochemical and spatial profiling analyses, and conducting RNA/DNA profiling on tumor samples and other tissues.

How You Will Achieve It
  • Evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity
  • Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development
  • Planning and execution of in vivo murine studies and ex vivo functional assessments, such as, complex human tumor/stroma/immune cell 3D assays, multi-color flow cytometry, Immunohistochemistry/immunofluorescence, and primary cell culture
  • Communication of experimental results to team

Qualifications

Must-Have

  • B.S. degree with 6+ years’ experience or MS (preferred) with 5+ years of experience
  • Experience in the fields of immunology, cell biology and/or genetics
  • Ability to plan and execute in vitro experiments with minimal supervision
  • Expertise in standard immunologic techniques
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, 3D spheroids, tumor explants and organoid assays that mimic human tumor microenvironment)
  • Experience with human PBMC and mammalian cell culture
  • Experience with qRT-PCR, ELISA, MSD, ELISPOT, Nano string and cytotoxic assays
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic

Nice-to-Have
  • Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry
  • Experience in CRISPR technology, lentiviral transduction, tumor explant and 3D spheroid assays
  • Experience working with biologics and small molecule inhibitors for tumor immunotherapy


PHYSICAL/MENTAL REQUIREMENTS

  • Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting.
  • Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.
  • Standard business office conditions; sitting, standing as appropriate
  • Infrequent travel (generally other Pfizer sites or professional meetings)

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

  • Lifting, sitting, standing, walking, bending, repetitive pipetting, ability to perform mathematical calculations, ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.
  • Occasional off-hour and weekend schedule.

#LI-PFE

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Company

Join world-class scientists and leaders who are dedicated to bringing therapies that will significantly improve patients' lives.

As one of the world's premier innovative biopharmaceutical companies, we're driven to discover the cure --driven to significantly improve the lives of everyone...everywhere. If you're similarly driven, you'll find there's no better place to begin --and continue --your career than at Pfizer.

Science is the foundation of our company.  This is why it's no surprise that the most driven scientists in the world choose to carry out their life's passion at Pfizer.  We arm them with the resources, technology, and facilities they need to solve some of the world’s most complex health challenges. This combination empowers our scientists with expertise in vaccines, small-molecule medicines, biotherapeutics amongst many others, to collaborate on breakthrough science, including the world's first mRNA-Based Covid19 vaccine.  Our colleagues advance science and technologies into the therapies that matter most.

Join us and you'll partner with colleagues of diverse backgrounds and abilities who contribute to all aspects of what we do. Great things happen when people come together with one shared goal. If you're driven to discover the cure- ensure it has the latest technology to make it a reality or help improve the lives of others- join those who are similarly driven at Pfizer. The future of medicine is happening here.

Visit www.pfizer.com and connect with us.

 

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Find Us
Website
Phone
(212) 733-2323
Location
235 East 42nd Street
New York, NY 10017
United States
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