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Scientist I, Protein Design (Bioinformatics/Data Science focus)

Mammoth Biosciences
Brisbane, CA
Start date
Sep 6, 2022
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Job Details

Mammoth is seeking a Scientist I with protein modeling and bioinformatic/data science experience to contribute to protein engineering efforts in  its growing Discovery team. The Discovery team is responsible for developing novel CRISPR-associated (Cas) nucleases for genome editing applications. 
The successful candidate will be responsible for generating molecular protein-nucleic acid models and using bioinformatics and machine learning approaches to contribute to protein engineering efforts. The candidate will also be responsible for building analysis and visualization tools for large screening datasets. This is an excellent development opportunity for researchers who want to learn new skills and start their career working on cutting-edge CRISPR technologies.
  • Generate protein-nucleic acid structural models and use machine learning approaches to inform enzyme  engineering efforts
  • Deploy data analysis and visualization tools for protein engineering campaigns
  • Design tools to support HTP molecular biology efforts for protein engineering campaigns
  • Analyze NGS datasets to interpret engineering outcomes and inform next steps
  • Provide regular updates at internal meetings
  • Other duties as assigned

  • Bachelor’s degree in a relevant scientific discipline +5 years industry experience, M.S. +3 years, or PhD
  • Expertise using protein modeling and structural analysis software applications (Rosetta, RoseTTAFold, AlphaFold, etc.) 
  • Python programming skills and experience using common bioinformatics software (BioPython, BLAST, MMSeqs, HMMer)

  • Expertise in analyzing large datasets and applying machine learning approaches for to protein design and engineering
  • Hands-on experience in the following areas: molecular biology (PCR, DNA/RNA purification and quantitation); biochemical and cell-based assays; CRISPR gene editing in mammalian cells

  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law. 


Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more.

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Find Us
(650) 294-8583
South San Francisco
United States
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