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Scientist, Analytical Chemistry (LC-MS)

Regeneron Pharmaceuticals, Inc.
Tarrytown, New York
Start date
Sep 3, 2022
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Job Details

Our Analytical Chemistry Group is seeking a hard-working Scientist, Analytical Chemistry. Our Analytical Chemistry team develops innovative mass-spec related technologies to support Regeneron R&D programs in the context of multidisciplinary project teams.

In this role you will work in a groundbreaking analytical lab and lead analytical development and characterization of biotherapeutic drug candidates to support all stages of drug development, from early-stage selections to late-stage regulatory submissions.

A Typical Day in the Role Might Look Like:
  • Lead analytical development and characterization of biotherapeutics, including monoclonal antibodies, bispecifics, adeno-associated virus (AAV), RNA and other biotherapeutic drug profiles to support different drug development activities.
  • Develop analytical strategies and methods to elucidate and figure out quality attributes, risk assessment and control strategies, including PTMs, product and process related impurities, host cell proteins, charge variants, LMW/HMW species, sequence variants, etc. to address emerging challenges.
  • Provides analytical mentorship and support for formulation development, upstream/downstream functional groups, GMP manufacturing and QC to address real-time development issues in the process development and OOT/OOS investigations.
  • Presents work at the internal and external meetings; prepares and reviews development reports, memos, and regulatory submission documents in CMC (e.g., IND, IMPD, BLA, MAA, comparability and other study reports.) and peer-reviewed articles for publications;
  • Serve as the team representative and provides the knowledge and expertise of analytics to cross-function teams.

This Role Might Be For You If:

You have a PhD in chemistry or biochemistry with 0-5 years of industry experience, and proven record of publications. A strong background in LC-MS with biopharma experience especially in protein therapeutics or AAV analytics is desired.

  • Have a passion for science with strong leadership and motivation of making contributions in a team setting.
  • You possess an understanding of Analytical Chemistry, have strong organization and scientific skills to develop innovative mass spectrometry-related technologies and collaborate within a matrix environment to influence cross-functional teams & senior management
  • You have strong initiative to complete tasks and drive new technologies related to Formulation Development.
  • Having knowledge or experience in both upstream and downstream process development is preferred. Expertise in mass spectrometry principles and applications for protein characterization and process development, with keen analytical and problem-solving skills, especially for Orbitraps, GC-MS, ICP-MS, Q-TOF and/or Triple-quadruple MS systems desired.
  • Extensive hand-on experiences and trouble-shooting skills on separation science (e.g. U/HPLC, nanoLC, SEC, IEX, HIC, HILIC, 2D-LC, CE, iCIEF, etc.) needed. Proficiency in LC and MS-related software, such as Xcalibur, MassLynx, MassHunter, Proteome Discoverer, Byonics, Skyline, Empower desired.
  • Abilities in computer programming and bioinformatics a plus.
  • Experience with liquid handling and automation systems is a plus.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.


Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Find Us
Corporate Headquarters
777 Old Saw Mill River Road
New York
United States
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