The Abbvie Proteomics team at the DMPK-BA department (Worcester, MA) supports Abbvie drug discovery programs by providing critical data on therapeutic targets, disease mechanisms of action, in vitro and in vivo model characterization, and biomarker research. We are strengthening our team to allow expanding our capabilities in proteoform analysis which plays a critical role in drug discovery and development, with a focus on biomarker analysis and target characterization.
Proteoforms (protein isoforms and posttranslational modifications) play a critical role in drug discovery and development, including biomarker analysis and target characterization. At DMPK-BA, we are seeking a highly motivated Sr. Scientist candidate to join the quantitative proteomics and mass spec technology team at the Worcester, Massachusetts location. The research in proteoform analysis will support Abbvie drug discovery programs by providing critical support to develop biomarker assays and provide critical information on therapeutic targets.
What will you do?
In this role, the successful candidate will work in a highly collaborative environment including biomarker method development and mass spectrometry teams at DMPK-BA and across R&D. The candidates will apply their expertise to build innovative proteoform analytical capabilities to support biomarker method development and target characterization efforts by providing analysis, quantification, and characterization of proteoforms from relevant biological matrices including patient plasma, CSF, and tissue biopsies. The candidate will design, execute experiments, generate high-quality data, provide data analysis with result interpretation, and present in cross-functional project team meetings. The candidates will also have the opportunity to develop skills as a biomarker and/or project representative roles.
The successful candidate will be an expert in the field of proteoform analysis and quantitative proteomics, with a solid background in mass spectrometry-based technology and in-depth knowledge of current and emerging proteomics principles, which include quantitative proteomics based on bottom-up and top-down approaches, analysis of post-translational modifications, liquid chromatography-mass spectrometry for protein analysis using state-of-the-art high-resolution LC/MS instrument including Fusion Lumos, QE Orbitrap, TIMS-TOF, and TripleTOF. Familiar with biological sample preparation using immunoaffinity enrichment and proficiency with proteomics data analysis software. Experience in bioinformatics is highly desired but not required. General knowledge and passion for biomarkers, target characterization, and translational science are highly desirable.
Ph.D. in protein mass spectrometry, protein biochemistry, Analytical Chemistry, biology, or a PharmD in a related discipline with 0-4 years of industry or postdoctoral experience, or M.S. degree with 8+ years of related research experience.