Research Associate III/Sr.RA - Bioanalytical Operations

Manager: Scientist
Department: Development
Location: Richmond, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let’s build a better future together.

JOB SUMMARY:   
Sangamo Therapeutics is seeking a highly motivated Research Associate III/Sr. Research Associate with strong strategic and hands-on experience in bioanalysis to join Bioanalytical Operations. The successful candidate will be responsible for bioanalytical method development and qualification, sample testing, CRO identification, and assay outsourcing and monitoring to support nonclinical and clinical development programs in gene and cell therapy. The position requires adaptability to work in a team environment as well as independently. The work is exciting and fast-paced with a direct impact on the company's goals. 


ESSENTIAL FUNCTIONS: 

• Support bioanalytical method development, qualification/validation, testing, and technology transfer activities on nonclinical and clinical development programs
  • CRO evaluation and contract set up for assay outsourcing
  • Oversee contract works at CROs  
  • Interact with/train technologists at CROs
  • Oversee assay execution, report writing, timeline, and other deliverables
  • May need to handle multiple projects simultaneously and/or manage a complex project with multiple assays and priorities in a fast-paced team environment
  • May need to develop assay for method transfer and support sample testing
  • May need to work on critical reagent generation and characterization
• Work closely and efficiently with scientists and other associates internal or external to develop, troubleshoot, and qualify/validate various bioanalytical assays such as qPCR biodistribution, PK, PD biomarker, immunogenicity in various biological matrices to support nonclinical and clinical studies
• Work closely with clinical operations and clinical science for the conduct of clinical trials
• Monitor sample analysis based on established procedures and practices in-house or at CROs
• Make detailed observations, summarize data, present progress to the project team and/or other groups
• Participate in internal and external scientific meetings and discussion groups
• Maintain a high level of professional expertise and deep understanding of disease biology through familiarity with scientific literature.  Investigate, create, and develop new methods and technologies to address bioanalytical challenges for project advancement.

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• B.S. or M.S. in biochemistry, cell biology, molecular biology, chemistry, or related field with 3-6 years of relevant industry experience in a biotechnology company
• Extensive experience with development, qualification, and/or validation of quantitative pharmacokinetic/pharmacodynamics, immunogenicity, and biomarkers assays in a variety of biological matrices
• Good understanding and hands-on experience of bioanalytical methods such as LC-MS/MS, FACS, IHC/ISH, molecular biology techniques (e.g. PCR, qPCR), cell biology techniques (e.g. cell culture, cell-based assays), immunoassays (e.g. ELISA, MSD), and functional enzyme activity assays.
• Experience in bioanalytical LC-MS/MS, FACS, IHC/ISH assay transfer to CRO and assay monitoring is a strong plus
• Deep familiarity with regulatory guidances and industry white papers relevant to ligand-binding and other large-molecule analytical methods.  Experience in GLP environment is a plus.
• Demonstrated ability to troubleshoot and produce creative solutions
• Knowledge of Microsoft Office Suite and other relevant data analysis software (SoftMaxPro, JMP, Prism, etc.)
• Ability to work independently or in a team-oriented environment and with experience in managing complex projects
• Excellent written and interpersonal communications skills necessary to interface with CROs and team members; highly motivated and strong work ethic
• The job may require may require the ability for occasional travel to visit CROs

Sangamo is an equal opportunity employer
The above reflects management’s definition of essential functions for this position but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.

COVID-19

Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws. 

Note to External Recruiters: Please understand that we do not accept unsolicited resumes from any source other than from the candidates themselves. Any agency or independent recruiter must have a signed copy of our agency agreement before presenting candidates. Submission of unsolicited resumes without our signed agreement will not create any implied obligation on our part.