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Associate Scientist, Process Development - Downstream

Forge Biologics
Columbus, Ohio
Start date
Aug 13, 2022

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Job Details

Role Description:

We are currently seeking an Associate Scientist, Process Development - Downstream to join the Forge Biologics team.  This is an exciting entry-level opportunity to assist in the execution of laboratory experiments and protocols for downstream process development efforts. The candidate will assist in process development protocols/studies to optimize procedures for unique viral vector platform process and to assist in the transfer of client programs. The Associate Scientist will work to meet production goals, notify management of any potential delays in the schedule, and make recommendations to resolve the issues.

This position reports to Associate Director, Process Development - Downstream and is responsible for laboratory stocking, inventory management, and assisting in laboratory activities. This includes preparing growth media, chemical buffers, solutions or other reagents that involve the mixing of subcomponents and preparing raw materials for use in production steps. Work activities may also include performing laboratory techniques (vector purification and cell culture) in support of production of recombinant adeno-associated virus (rAAV) vectors. It is expected that you will work as a member of the development team while accomplishing the timely completion of assignments and reporting of unexpected technical issues.



  • Assist with overall maintenance of the production and testing facilities.  This includes but may not be limited to performing quality systems checks, buffer preparation, autoclaving of media, packing of biohazard material, monitoring or sanitizing equipment, preparing facility for production campaigns, and periodic cleaning of incubators, centrifuges, FPLCs, biological safety cabinets (BSCs), and other equipment
  • Culturing cells, performing transfections and/or infections with seed vectors, harvesting and lysing cells, and purifying vectors using density gradients, FPLC, or other techniques
  • Provide support in the receipt and distribution of incoming raw materials for research, preclinical, and clinical manufacturing
  • Unpack reagents, maintaining proper cold storage, restock supplies in storerooms or laboratories
  • Quarantine and prepare incoming raw materials intended for preclinical or clinical manufacturing for inspection and release
  • Assist in maintaining proper inventories of raw materials and consumables
  • Prepares formulations and raw materials as specified in protocols without the introduction of contaminants
  • Prepare sterile reagents as dictated by procedures or management by filtration or steam autoclaving
  • Maintains clean work environment in all work areas
  • Reports any discrepancies from protocols/study procedures or any materials preparation problems to management
  • Delivering results in a high paced environment
  • Package and ship finished product to clients in accordance with procedures and regulations
  • Additional responsibilities not listed may be assigned as needed by leadership



  • Bachelor’s degree in Biology, Chemistry, or relevant area; Associate’s degree with 2 years of relevant experience may be considered
  • Working knowledge of TFF and Chromatography techniques is preferred
  • Must be self-motivating, organized and proactive
  • Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve problems
  • Strong writing, verbal, and organizational skills are essential
  • Ability to work hours necessary to support production and/or product transfer activities
  • Ability to work in loud noise environments and in Personal Protective Equipment (PPE) and cleanroom gowning attire as needed
  • Ability to lift 50 lbs
  • In our commitment to safety of our employees and customers a COVID vaccination is required.


Forge is a gene therapy development engine, focused on enabling access to life changing gene therapies and helping bring them from idea into reality. We partner with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups. We bring expertise in gene therapy manufacturing and therapeutics development to the table, helping champion teams that are navigating the long road from the lab bench to the bedside. With a patients-first approach, we are forging new models for working together to better accelerate these transformative medicines to reach those who need them most.

Find Us
3900 Gantz Rd
Grove City
United States
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