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Scientist I, Formulation/Pharmaceutical Development (Remote)

Global Blood Therapeutics
Working from Home
Start date
Aug 12, 2022

View more

Science/R&D, Biotechnology
Required Education
Masters Degree/MBA
Position Type
Full time
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Job Details


Position Summary:

Scientist I – Formulation/Pharmaceutical Development will help conduct pre-formulation, formulation development, tech transfer and manufacturing activities with the goal of developing robust oral and parenteral formulations for preclinical and early phase clinical programs.

Essential Duties and Responsibilities:

  • Design and conduct pre-clinical/clinical formulation development activities for various dosage forms
  • Perform pre-formulation studies such as physico-chemical characterization, pH solubility, excipient compatibility studies etc. and interpret data
  • Support the pharmaceutical development team with clinical phase drug product formulation development, tech transfer to CMO and GMP manufacturing
  • Manufacture solid dose formulations and characterization using bulk/tap density, hardness, thickness, friability, disintegration and dissolution profiles at GBT
  • Execute statistical design of experiments (DoE) studies to evaluate formulations and process
  • Design and execute stability protocols along with the analytical development group for accelerated and long-term stability
  • Manage, set up and maintain all the equipment in the formulation lab
  • Maintain inventory of supplies, chemicals and excipients needed for the formulation lab
  • Perform tasks per protocols and develop new protocols as needed
  • Draft reports and present results to colleagues. Other Duties as assigned
  • Approximately 15% travel may be needed for scientific project management and monitoring of critical project activities


  • MS with 3-6 years or Ph.D. with 1 – 2 years’ experience in pharmaceutical sciences, chemistry, chemical engineering, or related discipline
  • Absolutely require hands-on laboratory experience in pre-formulation, some solid-state characterization and pharmaceutical unit operations (tablet/capsule granulations, milling, tablet compression, tablet coating etc.)
  • Experience with formulation development of therapeutic agents (small molecules and/or peptides)
  • Independent problem-solving and troubleshooting abilities
  • Excellent data analysis skills with attention to detail and interpretation of results
  • Excellent oral and written communication skills
  • Demonstrated track record of completion of development reports
  • Ability to work independently and in a team environment

Fit with GBT culture:

  • Ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Values-based leadership consistent with GBT's Core Values
  • Excitement about the vision and mission of GBT
  • Flexibility
  • Integrity

NOTE:  This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities.  The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.



Global Blood Therapeutics (GBT) is a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. Founded in 2011, GBT is delivering on its goal to transform the treatment and care of sickle cell disease (SCD), a lifelong, devastating inherited blood disorder. The company has introduced Oxbryta® (voxelotor), the first FDA-approved treatment that directly inhibits sickle hemoglobin polymerization, the root cause of SCD. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. In addition, GBT’s drug discovery teams are working on new targets to develop the next generation of treatments for SCD. To learn more, please visit and follow the company on Twitter @GBT_news.

Find Us
181 Oyster Point Blvd
South San Francisco
United States
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