Principle Research Associate / Research Scientist, DMPK-Clinical Pharmacology

IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage synthetic lethality-focused precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.
 
IDEAYA has an industry leading platform and pipeline in Synthetic Lethality. IDEAYA has established strategic collaborations with Amgen and Pfizer supporting its pipeline programs, and also has wholly-owned or controlled clinical and preclinical programs. For more information, please see www.ideayabio.com.

Position Summary:

The DMPK-Clinical Pharmacology Department at IDEAYA Biosciences is searching for a Principal Research Associate / Research Scientist. The primary responsibility of this role is to support bioanalysis for PK and PK-PD-Efficacy studies desired to characterize the absorption, distribution, metabolism, excretion, and PK-PD properties of small molecule drug candidates from early discovery through clinical stage development.

What you'll do:

• Perform bioanalysis supporting PK, PK-PD studies including LC-MS/MS method development and sample analysis in biological matrices
• Conduct PK analysis supporting preclinical studies. 
• Develop DMPK assays including in vitro ADME and biomarker analysis as needed 
• Generate and upload assay data, communicate results/reports to multi-disciplinary project teams
• Work closely with multi-disciplinary team
• Maintain good electronic laboratory notebook records
• Write and review study/assay protocols and reports as required
• Perform routine instrument maintenance and troubleshoot as needed
• Participate in the coordination of external CROs for contract/quote management, study request, execution, and timelines. 

Requirements

• A degree of Ph.D. (with 0-2 industrial experiences) or BS/MS (with a minimum of 7 years industrial experiences) in DMPK, Chemistry, Pharmacology, Pharmaceutical sciences or related discipline
• Required skillset includes hands-on experience in biological sample extraction methods, HPLC-MS method development, and operating state-of-art HPLC-MS instruments. Working knowledge in other in vitro ADME assays is a plus.
• Understanding of ADME-PK principles and the application of ADME-PK information supporting early discovery, lead optimization and/or development of candidate selection 
• Excellent communication and organizational skills, proven ability to work in a team-based environment are essential

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities, with partial work-from-home flexibility,  and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

Benefits
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

California Job Applicant Privacy Notice