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Scientist / Engineer, Process Development

Employer
Pfizer
Location
Andover, Massachusetts
Start date
Aug 11, 2022
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Job Details

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Manufacturing Sciences and Technology (MSAT) at Pfizer is looking for a highly motivated, versatile candidate to join our multidisciplinary team of scientists and engineers in Andover, MA. The group supports Pfizer’s portfolio of late stage development and commercial biopharmaceuticals and vaccines, and is responsible for process troubleshooting, process improvements and second- generation process development. We are looking for someone who is eager to contribute independent thinking and technical excellence to the upstream cell culture and fermentation team.

The ideal candidate will be a valuable contributor to the upstream team within MSAT Andover. The role is well-integrated with the rest of the MSAT group and will involve a lot of collaborative work both within the group and across the Andover site.

In this role, the candidate will be responsible for design and execution of bioreactor experiments in bench-top and Small Scale SIP bioreactors and associated scale-down equipment with the goal of developing robust, scalable, and high productivity processes that produce biotherapeutics with appropriate product quality attributes to treat human diseases. The candidate will also collaborate with manufacturing operations in process improvement & robustness initiatives and technical investigations as a subject matter expert to ensure product supply. The colleague may also be involved in innovation and technology development projects that seek to improve production processes both from a process engineering as well as a biological perspective that have the potential to increase process performance.

How You Will Achieve It
  • Regularly contribute and influence at the project team level.
  • Apply technical and functional knowledge to design and execute experiments independently.
  • Support technology transfer of drug substance processes to internal Pfizer drug substance manufacturing facilities and external suppliers.
  • Assist the compliance activities on safety and regulatory requirements that are expected and documented through the internal training program.
  • Serve as the Technical Expert for the manufacturing methods, perform scientific laboratory studies, and make recommendations to improve manufacturing reliability, cost, safety, compliance and environmental performance.
  • Remain current with biotechnology literature and applications of continuous development and manufacture.
  • Select, develop, and apply new and existing process technologies to facilitate process design to achieve project goals.
  • Assist with definition and tracking of document management plan.
  • Execute lab-based studies to improve productivity and/or robustness of licensed processes.
  • Communicate appropriately on activities and progress to management and key stakeholders.
  • Take personal responsibility for own work, pushing self and others to exceed goals and deliver results.

Qualifications

Basic Qualifications

  • Bachelor’s degree in a relevant discipline with 5+ years of experience in biotechnology
  • Master’s degree in a relevant discipline with 3+ years of experience in biotechnology
  • Ph. D. in a relevant discipline with 0-4 years of experience in biotechnology
  • Proficient in aseptic technique (required)
  • Proficient in bioreactor operation and associated analytical tools (required)
  • Experience with cell culture and/or bacterial fermentation (required)
  • An in-depth knowledge of bioreactor operations fed-batch, perfusion, and continuous modes of cell culture
  • Strong trouble-shooting skills and extreme attention to detail required
  • Qualified candidates will serve as an upstream and biochemistry resource for the department and project teams, while proactively keeping historical product knowledge and experience.

Preferred Qualifications

  • Prior experience developing and maintaining scale down models of commercial biopharmaceutical processes
  • Prior experience in developing commercially relevant cell culture processes to produce pharmacologically active proteins
  • Experience with control and data acquisition systems
  • Demonstrated experience developing or introducing new technology into commercial processes
  • Knowledge of all aspects of cell culture/fermentation, including batch, fed-batch, perfusion and harvest/clarification operations
  • Familiarity with DoE and other statistical tools
  • Experience with processing and interpreting large data sets
  • Familiarity with regulatory filings, cGMP requirements and operational constraints
  • Knowledge and experience with international CMC regulatory requirements and {Current} Good Manufacturing Practices


PHYSICAL/MENTAL REQUIREMENTS

Involves typical bioprocessing lab activities

Ability to routinely lift 30 Lbs,

Standing for prolonged periods

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

  • May require some out of hours working to support laboratory work or participation in teleconferences with other global sites.
  • Some travel may be required, but is not expected to be a standard aspect of role (<5% time)

Last Date to Apply: August 17 2022

Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Company

Join world-class scientists and leaders who are dedicated to bringing therapies that will significantly improve patients' lives.

As one of the world's premier innovative biopharmaceutical companies, we're driven to discover the cure --driven to significantly improve the lives of everyone...everywhere. If you're similarly driven, you'll find there's no better place to begin --and continue --your career than at Pfizer.

Science is the foundation of our company.  This is why it's no surprise that the most driven scientists in the world choose to carry out their life's passion at Pfizer.  We arm them with the resources, technology, and facilities they need to solve some of the world’s most complex health challenges. This combination empowers our scientists with expertise in vaccines, small-molecule medicines, biotherapeutics amongst many others, to collaborate on breakthrough science, including the world's first mRNA-Based Covid19 vaccine.  Our colleagues advance science and technologies into the therapies that matter most.

Join us and you'll partner with colleagues of diverse backgrounds and abilities who contribute to all aspects of what we do. Great things happen when people come together with one shared goal. If you're driven to discover the cure- ensure it has the latest technology to make it a reality or help improve the lives of others- join those who are similarly driven at Pfizer. The future of medicine is happening here.

Visit www.pfizer.com and connect with us.

 

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Find Us
Website
Phone
(212) 733-2323
Location
235 East 42nd Street
New York, NY 10017
United States
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