.Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.
The In Vivo Pharmacology Department searching for a Senior Scientist with experience in in vitro/ex vivo and in vivo pharmacology study execution and data analysis. This person will support the strategy and coordination of operations of the team with future growth in leading the team in the areas of cell derived xenograft (CDX) and patient derived tumor xenograft (PDX) areas. The person will be responsible for hands-on laboratory work, including PDX tumor processing, bank management, and tumor model development. Additionally, the role involves tumor model selection and in vivo pharmacology study designs as a representative member on project teams for development of novel cancer therapeutics. The scientist will collaborate with in vitro biology, translational/biomarkers, toxicology, clinical research, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The ideal candidate will be highly motivated, work independently, collaborative with multi-disciplinary teams and have extensive skills in the field of oncology.
- Management of operations of ex vivo and in vivo studies and the team, including coordination of study designs and timelines/resources
- Hands-on expertise to design complex in vivo experiments utilizing tumor models in immunocompetent mice and in approaches to enhance in vivo evaluation of novel therapeutics.
- Uses detailed knowledge of state-of-the-art tools (e.g.: multicolor flow cytometry, FACS, scRNAseq, WES) to access oncology target identification, validation, and modulation levels
- Strategize, design, and analyze data from in vivo studies testing novel therapeutics involving CDX, PDX, orthotopic models, syngeneic models, etc. for various cancer subtypes
- Demonstrates a high level of initiative in troubleshooting experiments and performing data analysis
- Effectively collaborates across all intra and cross functional teams
- Presents research findings to project teams and governance bodies and prepare technical reports
- Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases
- Sr. Scientist I, PhD degree with no experience or
- Sr. Scientist II, Phd degree with 4 years of experience in Cancer biology, Pharmacology, or related field.
- Possess theoretical and practical understanding of mouse oncology models, including CDX (required) and PDX models (preferred)
- Excellent laboratory, record keeping, data analysis and critical thinking skills
- Ability to plan, execute, and troubleshoot experiments
- Strong organizational skills, attention to detail, and time-management skills enabling efficiency and independence
- Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment
- Demonstrated excellence and productivity in independent research
- Strong written and verbal communication skills
- Scientific leadership abilities and collaborative personality
- Effective writer and communicator of research materials
- Willing to have schedule flexibility
**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**