This job has expired

You will need to login before you can apply for a job.

Director, Clinical Pharmacology

Employer
Ambrx, Inc.
Location
La Jolla, CA
Start date
Aug 10, 2022

View more

Discipline
Clinical, Clinical Research, Science/R&D, Pharmacology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Beach
You need to sign in or create an account to save a job.

Job Details

About Ambrx: 

Ambrx Inc. is a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code. Ambrx technology uses an expanded genetic code to incorporate synthetic amino acids into protein, all completed within a living cell. These synthetic amino acids enable the creation of Precision Biologics, an exciting new class of therapeutics with broad application and potential. This includes next-generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as smart cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease.

 Job Description:

We are seeking a talented and motivated individual for the position of Director in Clinical Pharmacology & Pharmacometrics (CPP). In this role, you will function as a clinical pharmacology lead on project teams to drive the clinical pharmacology and model-informed drug development strategy for oncology and immune-oncology programs across all clinical development stages. In addition, you will apply clinical pharmacology knowledge to inform design of clinical pharmacology studies or clinical pharmacology component of clinical studies, conduct pharmacokinetics (PK) / pharmacodynamics (PD) analyses, and draft analysis reports.

Responsibilities:

  • Representing CPP and providing subject matter expertise on cross-functional project teams
  • Leading clinical pharmacology programs supporting clinical development for ADCs in oncology
  • Developing CPP plan and content for interactions with health authorities
  • Authoring/reviewing clinical protocols, analysis plans, study reports, and regulatory submissions (e.g., INDs, IBs, BLAs etc.)
  • Performing pharmacometric analyses and drafting reports for population PK and exposure-response analyses
  • Managing third-party vendors to ensure timely delivery of high-quality study reports

Qualifications

  • PhD or equivalent degree in Clinical Pharmacology, PK, Pharmaceutical Sciences, Biomedical Engineering, or a related scientific discipline with 5+ years’ experience
  • In-depth knowledge of PK, PD, and/or translational sciences.
  • Hands-on experience with PK/PD analysis using software programs (e.g., WinNonlin, NONMEM, R etc.)
  • Good oral and written communication skills and ability to convey analysis findings clearly
  • Ability to assess, prioritize and manage a diverse, time-sensitive workload

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.

Company

Ambrx®, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics using an expanded genetic code. Unlike conventional conjugation techniques that create a mixture of suboptimal molecules, Ambrx technology combines site specific conjugation with proprietary linkers, payloads and pharmacokinetic extenders to create a single molecular species that is optimized for safety, efficacy and biophysical properties. We call this process Protein Medicinal Chemistry™.

Protein Medicinal Chemistry™ can optimize any protein or antibody to create potentially best-in-class therapeutics such as long-acting proteins, bi-specifics and antibody drug conjugates. The Ambrx advantage allows us to safely and effectively target cytotoxic agents or recruit effector function to tumor cells (oncology) or modulate biological pathways implicated in disease areas such as autoimmune, metabolic and cardiovascular.

At Ambrx, we are dedicated to assembling and developing an exceptional team and a novel technology to create the next generation of protein-based medicines.

Find Us
Website
Phone
858-875-2400
Location
10975 North Torrey Pines Road
La Jolla
California
92037
United States
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert