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Scientist II

Employer
Frederick National Laboratory for Cancer Research
Location
Frederick, MD
Start date
Aug 10, 2022

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Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
BioCapital
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Job Details

Scientist II

Job ID: req2785
Employee Type: exempt full-time
Division: Laboratory Animal Science Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION         

The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals

 KEY ROLES/RESPONSIBILITIES

  • Contribute to scientific, methodological, operational, and logistical oversight of multiple projects that vary in complexity, scope of objectives, number and breadth of participating collaborator organizations, as well as anticipated requirements of budgetary, labor, animal and other resources.
  • Instrumental in identifying the need, ensuring timely availability, documentation compliance, and assisting in coordinating project efforts with other scientific core facilities, such as small animal imaging program, molecular histopathology laboratory, high-throughput genotyping and animal diagnostic facilities, molecular cores at Cancer Research and Technology Program, etc.
  • Initiate, promote, and facilitate project scientific communications among members of CAPR team at all levels, including periodic scientific data exchanges, interim project status updates, key final deliverables such as project reports, publications, press-releases, and meeting presentations.
  • Provide support to the PTOT team leader in managing communications with multiple intramural and extramural collaborators, assisting in preparing for periodic project status meetings, new proposal evaluation, and developing interim and final project reports.
  • Scientific activities of this position will embrace and expand recently initiated endeavors of CAPR leadership to conduct the multi-aspect evaluation of immunologic landscapes in cancer disease and immune-oncology (IO) patterns in a spectrum of GEM models for the purpose of target identification and validation of promising IO therapeutic regimens.
  • Adoption and application of recent technologic advancements in preclinical disease modelling (such as rapid engineering of modified alleles and somatic modeling of cancer disease enabled by CRISPR/Cas9 genome editing tools) and integrated state-of-art analyses of novel preclinical models for the purpose of informative assessment of efficacious therapeutic strategies will constitute another important contribution of this employee.
  • Assist team leader in acquiring and managing team assets (e.g. new animal models or other research tools), preparing project accountability documentation, monitoring the availability and quality of mission-critical resources (such as experimental animals, cell culture and molecular biology regents, relevant equipment and instrumentation, etc.), inventorying project-generated assets (e.g. tissue and biological fluid biobanks); as well as provide input in planning, budgeting, and scheduling of upcoming projects.

BASIC QUALIFICATIONS

 To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a (CHEA) PhD or an MD (or a combination) degree from an accredited college or university according to the Council for Higher Education Accreditation.
  • Foreign degrees must be evaluated for U.S. equivalency.
  • Two (2) years of relevant experience in conducting basic or translational studies preferably in disease animal models, with an emphasis on characterization and employing for preclinical drug development objectives genetically or biologically engineered, or patient-derived xenograft murine models.
  • Deep understanding of foundations of cancer biology, cancer disease initiation and progression, molecular analyses, cancer drug target identification and therapeutic development.
  • Well-developed self-organization, project planning/documentation, time management skills, independent completion of experimental tasks.
  • Expertise in computer-based data acquisition, management and data analysis.
  • Ability to design, plan, conduct, troubleshoot, and continuously optimize vigorous, complex integrated multidiscipline preclinical research workflows in advanced mouse cancer models.
  • Extensive communication and presentation skills, ability to prepare comprehensive informative project documentation and other written or oral deliverables, such as manuscripts, meeting abstracts, scientific presentations and seminars, etc. 
  • Prior research accomplishments documented e.g. in the form of significant publications in peer-reviewed journals, meeting poster presentations, invited talks, and other evidences of scientific achievements.
  • Ability to obtain and maintain a security clearance.

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • Deep understanding of the evolving experimental strategies and technologies in translational science/medicine including such technologic highlights as next-generation DNA and RNA sequencing, other techniques of gene expression profiling, tissue micro arrays, immunohistochemistry (IHC), cytology, in situ hybridization (ISH), systems biology and multi-omics platforms, cell-based assays and genome editing methodologies.
  • Demonstrated knowledge of current research trends and priority directions in translational science, with the emphasis on cancer biology, preclinical cancer modeling, diagnostic and therapeutic drug development.
  • Prior exposure to project management experience in a research setting focused on translational or preclinical workflows.
  • Prior experience in preclinical drug development workflows is a strong plus for a resume of interested applicants.
  • Experimental exposure to, or working knowledge of, various genome modification technologies, ranging from homologous recombination in embryonic stem cells to genome editing by targeted nucleases (e.g. CRISPR/Cas9 technology) is considered a strength for an applicant seeking this appointment.
  • Basic understanding of regulatory requirements for Investigational New Application (IND) submission will strengthen the application, as well as an entry level knowledge of technology transfer processes and material transfer/collaborative documentation.
  • Experience in engineering and analyses of murine cancer models for pancreatic, thyroid, or neuroendocrine tumors.
  • Experience or knowledge of patient-derived xenograft (pdx) models for the aforementioned cancer types.

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to animal(s) and/or animal
    material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring
    medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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Company

A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take

 

 

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Find Us
Website
Phone
301-846-1000
Location
8560 Progress Drive
Frederick
MD
21701
United States
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