Job ID: req2785
Employee Type: exempt full-time
Division: Laboratory Animal Science Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services that are focused on the design, generation, characterization and application of genetically engineered and biological animal models of human disease, which are aimed at the development of targeted diagnostics and therapies. LASP contributes to advancing human health, developing new treatments, and improving existing treatments for cancer and other diseases while ensuring safe and humane treatment of animals
to scientific, methodological, operational, and logistical oversight of
multiple projects that vary in complexity, scope of objectives, number and
breadth of participating collaborator organizations, as well as anticipated
requirements of budgetary, labor, animal and other resources.
in identifying the need, ensuring timely availability, documentation
compliance, and assisting in coordinating project efforts with other scientific
core facilities, such as small animal imaging program, molecular histopathology
laboratory, high-throughput genotyping and animal diagnostic facilities,
molecular cores at Cancer Research and Technology Program, etc.
promote, and facilitate project scientific communications among members of CAPR
team at all levels, including periodic scientific data exchanges, interim
project status updates, key final deliverables such as project reports,
publications, press-releases, and meeting presentations.
support to the PTOT team leader in managing communications with multiple
intramural and extramural collaborators, assisting in preparing for periodic
project status meetings, new proposal evaluation, and developing interim and
final project reports.
activities of this position will embrace and expand recently initiated
endeavors of CAPR leadership to conduct the multi-aspect evaluation of
immunologic landscapes in cancer disease and immune-oncology (IO) patterns in a
spectrum of GEM models for the purpose of target identification and validation
of promising IO therapeutic regimens.
and application of recent technologic advancements in preclinical disease
modelling (such as rapid engineering of modified alleles and somatic modeling
of cancer disease enabled by CRISPR/Cas9 genome editing tools) and integrated
state-of-art analyses of novel preclinical models for the purpose of
informative assessment of efficacious therapeutic strategies will constitute
another important contribution of this employee.
team leader in acquiring and managing team assets (e.g. new animal models or
other research tools), preparing project accountability documentation,
monitoring the availability and quality of mission-critical resources (such as
experimental animals, cell culture and molecular biology regents, relevant
equipment and instrumentation, etc.), inventorying project-generated assets
(e.g. tissue and biological fluid biobanks); as well as provide input in
planning, budgeting, and scheduling of upcoming projects.
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a (CHEA) PhD or an MD (or
a combination) degree from an accredited college or university according to the
Council for Higher Education Accreditation.
- Foreign degrees must be evaluated for U.S. equivalency.
- Two (2) years of relevant experience
in conducting basic or translational studies preferably in disease animal
models, with an emphasis on characterization and employing for preclinical drug
development objectives genetically or biologically engineered, or
patient-derived xenograft murine models.
- Deep understanding of foundations
of cancer biology, cancer disease initiation and progression, molecular
analyses, cancer drug target identification and therapeutic development.
- Well-developed self-organization,
project planning/documentation, time management skills, independent completion
of experimental tasks.
- Expertise in computer-based data
acquisition, management and data analysis.
to design, plan, conduct, troubleshoot, and continuously optimize vigorous,
complex integrated multidiscipline preclinical research workflows in advanced
mouse cancer models.
- Extensive communication and
presentation skills, ability to prepare comprehensive informative project
documentation and other written or oral deliverables, such as manuscripts,
meeting abstracts, scientific presentations and seminars, etc.
- Prior research accomplishments
documented e.g. in the form of significant publications in peer-reviewed
journals, meeting poster presentations, invited talks, and other evidences of
- Ability to obtain and maintain a security clearance.
Candidates with these desired skills will be given preferential consideration:
- Deep understanding of the
evolving experimental strategies and technologies in translational
science/medicine including such technologic highlights as next-generation DNA
and RNA sequencing, other techniques of gene expression profiling, tissue micro
arrays, immunohistochemistry (IHC), cytology, in situ hybridization (ISH),
systems biology and multi-omics platforms, cell-based assays and genome editing
- Demonstrated knowledge of current
research trends and priority directions in translational science, with the
emphasis on cancer biology, preclinical cancer modeling, diagnostic and
therapeutic drug development.
- Prior exposure to project
management experience in a research setting focused on translational or
- Prior experience in preclinical
drug development workflows is a strong plus for a resume of interested
- Experimental exposure to, or
working knowledge of, various genome modification technologies, ranging from
homologous recombination in embryonic stem cells to genome editing by targeted
nucleases (e.g. CRISPR/Cas9 technology) is considered a strength for an
applicant seeking this appointment.
- Basic understanding of regulatory
requirements for Investigational New Application (IND) submission will
strengthen the application, as well as an entry level knowledge of technology
transfer processes and material transfer/collaborative documentation.
- Experience in engineering and
analyses of murine cancer models for pancreatic, thyroid, or neuroendocrine
- Experience or knowledge of
patient-derived xenograft (pdx) models for the aforementioned cancer types.
- This position is subject to working with or have potential for exposure to animal(s) and/or animal
- This position is subject to working with or have potential for exposure to infectious material, requiring
medical clearance and immunizations
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)