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Senior Scientist, Pharmacology

Maze Therapeutics
South San Francisco, CA
Start date
Aug 9, 2022

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Science/R&D, Biotechnology, Pharmacology
Required Education
Position Type
Full time
Biotech Bay
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Job Details

About Maze Therapeutics

Maze is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into as many new therapies for patients as possible. 

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values  

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

Role Description:

A self-motivated, organized, and skilled senior pharmacologist with considerable experience in preclinical pharmacodynamic and disease models. The successful candidate will play a key role in planning, designing, and conducting efficacy studies to support Maze’s research projects and in preclinical pharmacodynamic and disease model development. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.​

Your Impact Includes:

  • Represent the Pharmacology department on multiple project teams
  • Plan, design and conduct in vivo preclinical studies to demonstrate target engagement or efficacy in disease models to support drug candidate discovery and development
  • Lead efforts to identify biomarkers that may have clinical utility
  • Generate key data to provide preclinical POC for novel mechanistic targets
  • Collaborate and coordinate seamlessly with other functional groups and project team members to deliver on program goals
  • Lead disease model development activities
  • Process, interpret, and document scientific results and communicate findings
  • Manage, productively, more junior colleagues, and CROs/academic collaborators, as required


  • PhD in relevant field, and 4+ years’ experience in pharmacology or related discipline within a pharmaceutical company
  • Considerable experience designing and executing rodent pharmacology studies
  • Experience in rodent dosing via multiple routes of administration, and biological sample collection and processing for biomarker evaluation
  • Experience in basic molecular biology techniques
  • Ability to work independently as well as contribute actively to an integrated team
  • Flexibility to work in a variety of therapeutic indications, and eagerness to learn new techniques and develop novel disease models
  • Highly motivated, with excellent interpersonal and communication skills
  • Some experience with histological techniques a plus
  • Experience with neurological, cardiometabolic and/or renal disease models a plu
  • Experience in managing more junior colleagues



Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Find Us
171 Oyster Point Blvd, Suite 200
South San Francisco
United States
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