This job has expired

You will need to login before you can apply for a job.

Research Scientist II, Chemical Development

Global Blood Therapeutics
South San Francisco, CA
Start date
Aug 9, 2022

View more

Regulatory, Science/R&D, Biotechnology, Research
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay
You need to sign in or create an account to save a job.

Job Details


Position Summary:

Global Blood Therapeutics, Inc. (GBT) is seeking a Research Scientist II in Chemical Development who will be responsible for the process chemistry and scale up activities related to the clinical development and manufacturing of small molecule programs. GBT places a high value on cooperative team dynamics and a positive, “can-do” work ethic. The ideal candidate thrives in a fast-paced environment where a strong sense of urgency is the norm and exceptional communication and interpersonal skills are needed.

 Essential Duties and Responsibilities:

  • Design and execute synthetic sequences with the intent for optimization and scale up
  • Present results of experiments, independently interpret data, and draw conclusions regarding results of laboratory work
  • Work on complex problems where analysis of situations or data require comprehensive evaluation of many factors
  • Provide technical support to drug substance development, including impurity control strategies and process route development
  • Demonstrate skills in data analysis (ex: UPLC, HPLC, NMR, mass spec) and ability to evaluate quality of data
  • Accountable to summarize studies, generate, review and approve necessary reports to provide scientifically sound and data-based support of chemical development
  • Apply relevant regulatory guidance (cGMPs, ICH, CFR) in daily work and work planning
  • Up to 20% travel may be needed for scientific project management and monitoring of critical project activities


  • PhD in synthetic organic chemistry, or BS/MS in chemistry with extensive industrial process chemistry experience
  • Chemical development experience with synthesis and crystallizations of heterocycles and chiral molecules preferred
  • Sensitive to timelines and solution oriented
  • Familiar with cGMPs, USP and ICH guidelines and industry best practices
  • A strong chemist who leads with data and understands the requirements for process development and GMP manufacturing
  • Familiarity with physical and chemical characterization of drug substances and drug substance intermediates
  • Excellent written and verbal communications skills required
  • Comfort working in multi-disciplinary teams, learning new skills and proactively solving problems

 Fit with GBT culture:

  • Ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Values-based leadership consistent with GBT's Core Values
  • Excitement about the vision and mission of GBT
  • Flexibility
  • Integrity

NOTE:  This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.  This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities.  The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law).  Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law.  The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.



Global Blood Therapeutics (GBT) is a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. Founded in 2011, GBT is delivering on its goal to transform the treatment and care of sickle cell disease (SCD), a lifelong, devastating inherited blood disorder. The company has introduced Oxbryta® (voxelotor), the first FDA-approved treatment that directly inhibits sickle hemoglobin polymerization, the root cause of SCD. GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. In addition, GBT’s drug discovery teams are working on new targets to develop the next generation of treatments for SCD. To learn more, please visit and follow the company on Twitter @GBT_news.

Find Us
181 Oyster Point Blvd
South San Francisco
United States
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert