Scientist- Physiologically-Based Biopharmaceutical Modeling (PBBM)

HOW MIGHT YOU DEFY IMAGINATION?

Youve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge youve worked hard to acquire and the passion you already have. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Scientist- Physiologically-Based Biopharmaceutical Modeling (PBBM)

Live

What you will do

Lets do this. Lets change the world. In this role you will join Amgens Pre-Pivotal Drug Product technologies organization as a member of our Synthetics Enabling Technologies Organization. We are seeking a highly motivated Scientist with expertise in biopharmaceutical in silico modeling to support synthetic preclinical formulation development, molecule assessment and form screening. You will join a team coordinating with partners to identify clinical candidates that are patient centric and differentiated from the competition to better serve an expanded patient population. Specifically, the successful candidate will:

• Support preclinical formulation development, lead optimization, and form selection to meet preferred product presentations for synthetics programs.
• Provide expertise in Physiologically-Based Biopharmaceutical Models (PBBM) and conduct assessments using in silico packages such as GastroPlus.
• Support early clinical development for synthetics liquid dosage forms (e.g. drug-in-bottle, parenteral) and technical transfers to support clinical manufacturing (GMP).
• Build and maintain strong working relationships with internal and external partners, including counterparts across R&D and Process Development, Business Development, and Amgens synthetics and biologics drug product organizations.
• Partner with process teams to ensure pipeline deliverables are met on schedule and at a high quality.
• Contribute to technical documents and regulatory filings: IND and NDA, technical protocols, technical reports, regulatory documents, patents, etc.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

Basic Qualifications:

• Doctorate or Doctorate degree completed by September 2022 Or
• Masters degree & 4 years of scientific experience Or
• Bachelors degree & 6 years of scientific experience

Preferred Qualifications:

• Doctorate Degree in one of the following areas: Pharmaceutical Sciences, Pharmacy, Chemistry, Chemical Engineering, Biological Sciences or related field with 1-2 years of postdoctoral or industry experience.
• Experience applying PBBM models using programs such as GastroPlus or SimcypTM.
• Working knowledge in preformulation concepts to evaluate the develop-ability of small molecule drug candidates.
• Direct experience with formulation and drug product process development.
• Experience in solidstate techniques (DSC, TGA, XRD, microscopy, DVS, particle characterization, Raman, IR, etc.)
• Knowledge of pharmaceutical science, analytical chemistry, and drug stability of synthetic and/or biologic modalities.
• A successful track record of peerreviewed journal publications and presentations.
• Excellent written, verbal, and presentation skills: ability to distill, craft and present key messages relative to diverse audience requirements.
• Problem solver with a proactive approach and independence to collaborate and work in a cross-functional and multidisciplinary environment.

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plancomprising health, finance and wealth, work/life balance, and career benefitswith compensation and benefits rated above 4 stars (out of 5) on Glassdoor
• Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

We equip all our staff members to live well-rounded, healthy lives. Most recently, Amgen added benefits for transgender employees and continues to pride itself on industry-leading, family-friendly offerings for families of all compositions.

Amgen focuses on areas of high unmet medical need and uses its expertise to strive for solutions that improve health outcomes and dramatically improve peoples lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the worlds leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com
Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States, Puerto Rico and Canada to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.