Discovery Scientist

Discovery Scientist – Waltham, MA

About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, Alloy democratizes access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Alloy’s lead offering, the ATX-Gx™ platform, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Alloy is a leader in bispecific antibody discovery and engineering services, utilizing its proprietary ATX-CLC common light chain platform integrating novel transgenic mice and phage display. Alloy is headquartered in Boston, MA with labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. As a reflection of Alloy’s relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

MAY THE BEST DRUG WIN.

About Discovery Scientist– Waltham, MA

Our Alloy Discovery Services group is looking for a Scientist to join our team in Waltham, Massachusetts. The position will report directly to our Head of B-Cell platforms and work with our Discovery Services team to build new antibody technologies to support the discovery of antibody-based therapeutics. You will be using the very latest single-cell techniques with the ultimate goal of helping others to make better medicines faster.

Principal Responsibilities

• Preparation of immune cells for screening on single-cell platforms (enrichment, FACS sorting)
• Assay development for single-cell screening
• Recovery of BCR sequences using single cell sequencing
• NGS library building
• BCR sequence analysis
• High throughput cloning of BCR

Required Qualifications and Skills

• PhD in Immunology, Molecular Biology, or related discipline with 0-2+ years of experience
• Experience with flow cytometry and FACS
• Experience with TCR and BCR sequencing methods
• Experience with RT-PCR and molecular biology protocols
• Experience with single-cell technologies (Beacon, Microfluidics, 10x genomics)
• Experience with next-generation sequencing
• Experience with sequencing of immune repertoire
• Solid knowledge of B cell and/or T cell biology
• Eager to pioneer new technologies to support drug discovery
• Attention to detail, rigorous scientific thinking and appropriate documentation, clear communication
• An independent sense of urgency, persistence, and integrity

Benefits Include 

• Competitive base salary based on the position and your experience level
• Significant opportunities for career advancement and mentorship inside Alloy, through our affiliated venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
• Generous equity compensation in a company with incredible growth potential and a 30+ year plan
• Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy, personal and business international travel health coverage, company-paid disability insurance, and an annual stipend for continuing education
• Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
• Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
• Additional benefits including adoption support over $40,000, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others