Research Associate, Protein Biochemistry

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit www.arvinas.com.

Position Summary

We are looking for a scientist to strengthen our protein purification and biochemistry team. We have built lab from the ground up, so the ideal candidate will be eager to use state-of-the-art instruments to solve difficult protein expression and purification problems to impact the entire Arvinas portfolio. This position will design protein constructs, express and purify proteins, perform QC, and contribute to characterization of ligand binding. This position will provide the key, critical data necessary to drive programs toward targeted degradation.

This position reports to the Structural Biology Research Investigator in our Platform Biology group and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Communicate with project lead to determine downstream application of protein, and conducting literature research to design soluble protein constructs with appropriate affinity and solubility tags. Downstream applications may include biophysics assays, protein crystallography, cryo-EM, and ligand screening.
• Expression of protein constructs in E. coli. including scouting in different cell lines and expression conditions, and sterile technique
• Experience in expression in mammalian or insect cells a plus
• Purification of proteins using affinity chromatography, IEX, and SEC.
• Quality control of protein preparation using SDS-PAGE and western blotting.
• Experience with additional quality control measures such as mass spectrometry or SPR/MST/ITC with known protein or small molecule binders a plus
• Apply excellent organizational and prioritization skills.

• Troubleshoot through technical and scientific challenges in order to deliver critical data.

• Organize experimental results to be shared with project teams; maintain clear experimental records and update

Qualifications

• A strong work ethic and theoretical knowledge in protein behavior and biochemistry. 
• Knowledge, theory behind, and experience with recombinant protein expression. Prior hands-on experience in analyzing protein-protein or protein-ligand interactions is a plus.
• Experience with AKTA protein purification systems, Unicorn software, Microsoft Excel is a plus.

Education

• Research associate – BS/MS in biochemistry, biotechnology, molecular biology, or related field and strong academic performace.
• Training in biophysical and/or structural biology techniques will be provided as needed.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer