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Director, mRNA-based Antigen Design – Vaccines Research

Employer
GreenLight Biosciences, Inc.
Location
Woburn, Massachusetts
Start date
Aug 7, 2022

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Discipline
Regulatory, Research/Documentation, Science/R&D, Research
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Genetown
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Job Details

ABOUT GREENLIGHT

At GreenLight we are working to solve two of the world's greatest problems: global food insecurity and equal access to vaccines and the associated health benefits. Unlike most corporations who can be required to put profits ahead of other principles, GreenLight is one of the first Public Benefit Corporations to be publicly traded and have a charter that requires a focus on how it benefits its employees, community and society and has a broad portfolio addressing key issues in plant health and human health (Nasdaq: GRNA) by leveraging the full potential of dsRNA and mRNA. The GreenLight team is over 300 people across our headquarters in Medford, MA, an R&D facility in Woburn, MA and an R&D facility in Research Triangle Park, NC. GreenLight also has a biomanufacturing plant in Rochester, NY. Initiatives include finding ways to support biodiversity, protect bees and other pollinators, treat rare diseases as well as develop vaccines.

At GreenLight, we believe inclusion is the way forward. We celebrate the power of working together to address humanity’s challenges, meet the needs of underserved populations, and push the boundaries of scientific discovery. Fueled by our aspiration for a true sense of belonging, our talented teams embody the principles of diversity and equality as we strive to bring food security, medicine, and healthcare to everyone—paving the way for a sustainable future. For more information, visit www.greenlightbio.com.

POSITION

GreenLight Biosciences is seeking a highly motivated, experienced molecular biologist to join the company as the Director of Antigen Design, Vaccines Research, to help advance the company’s vaccine R&D programs in the specific area of mRNA-based antigen design for vaccines. A deep background in molecular biology, RNA biology, plasmid DNA design and protein/peptide expression, and molecular optimization techniques are required along with a knowledge of vaccine antigen design and immunology. The Director of Antigen Design will report to the VP, Vaccines Research and will work closely with the other research departments and Human Health Clinical Development teams to execute on the scientific strategies and provide tactical oversight for GreenLight vaccines’ research portfolio. This is a great opportunity for a leader with strong scientific, operational, problem-solving and communication skills and ability who will manage and develop team of scientists and research associates.

 

MAJOR RESPONSIBILITIES

  • As head of the mRNA-based antigen design team, supervise/manage a team of PhD scientists and non-PhD research associates, performing in vitro and ex vivo studies in molecular biology, nucleic acid design and manipulations, nucleic acid bioanalytics, and using wide range of molecular and cell biology tools to drive vaccine antigen design, evaluation, and selection.
  • Provide scientific direction and leadership on molecular design and development of plasmid DNA vectors for optimal mRNA constructs that allow for efficient expression of vaccine antigens for prophylactic and therapeutic applications.
  • Recommend selection of vaccine antigen candidates based on optimal expression, physicochemical stability, and epitope presentation (that would contribute to desired immunogenicity outcomes in in vivo model systems).
  • Implement new instrumentations/techniques for molecular design and characterization of vaccine antigens and antibodies. Proactively identify, assess, and internalize emerging technologies and methods
  • Generate IP and participate in the drafting of patent filings.
  • Prepare and publish scientific papers.
  • Clearly communicate results and recommendations to colleagues, managers, and senior management in a timely manner, assisting in project decision-making.

 

PROFESSIONAL EXPERIENCE / QUALIFICATIONS

  • 10+ years’ experience in a research laboratory or biopharma/biotech company setting.
  • Significant experience in vaccinology with knowledge and extensive hands-on experience of molecular biology tools and techniques related to pDNA vectors design and manipulation, mRNA biology, and protein/peptide expression and characterization.
  • Understanding of vaccine/antibody discovery and development processes is highly desirable.
  • Ability to supervise a team of PhD scientists and non-PhD research associates and manage their scientific deliverables in a matrix environment.
  • Strong organization, communication, and interpersonal skills are required, with the ability to work both independently and in a collaborative internal and external work environment.

 

EDUCATION

  • Ph.D. in molecular biology, biochemistry, immunology or relevant field

Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

GreenLight requires proof of COVID-19 vaccination for its employees.

 

Company

GreenLight Biosciences is an integrated life sciences company with a cutting-edge platform to deliver higher-quality RNA at a lower cost and more quickly than was ever before possible.

GreenLight develops RNA products and collaborates with industry leaders to advance vaccine development, pandemic preparation, crop management, plant protection and support the health of bees and other pollinators. The GreenLight team values diversity, inclusion, and equality and promises to use collaboration to remain scientifically imaginative and passionately focused on making a difference in the world.

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Find Us
Website
Phone
617-716-7777
Location
200 Boston Avenue
Suite 1000
Medford
Massachusetts
02155
United States
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