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Senior Scientist/Scientist, Genome Editing Characterization

Employer
Fate Therapeutics
Location
San Diego, CA
Start date
Aug 7, 2022

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Discipline
Clinical, Science/R&D, Biotechnology, Genomics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Beach

Job Details

Fate Therapeutics is currently seeking a talented and motivated individual with expertise in molecular biology and next generation sequencing (NGS) to join a multidisciplinary team dedicated to discovery and productization of novel off-the-shelf cell-based immunotherapies.  Initially the candidate will develop and perform genome editing assays to support Fate’s gene editing platform and preclinical pipelines.  The position will evolve to include establishment of genomic analysis tools for NGS assays used in the manufacturing process and characterization of genetically engineered induced pluripotent stem cells (iPSCs).  Candidate is highly desired to master molecular biology techniques and to independently design and deliver high quality results to meet Fate’s aggressive timelines.  This is a full-time position reporting to a Principal Scientist and is located at the company’s corporate headquarters in San Diego, California.  
Responsibilities
  • Lead the molecular characterization team to develop and execute experimental plans to meet program and corporate research objectives and timelines and to mentor the junior team members. 
  • Design, optimize, and qualify molecular biology assays, including but not limited to PCR, qPCR, ddPCR, and sequencing for high-throughput, reliable, and in-depth characterization of genetic profiles of cell products following complicated genome editing experiments
  • Develop cutting edge molecular assays with the application of NGS technology, identify creative solutions to problems and invent new methodologies and workflows to improve sequencing technologies.
  • Develop lab automation (liquid handlers / plate readers, robotics) as needed for improvement of molecular biology assays
  • Standardize the methodologies and data analysis to establish statistical criteria
  • Use expertise and systematic problem-solving methods to troubleshoot and solve complex assay development issues
  • Must be team-oriented and able to communicate research and development findings in cross-disciplinary team meetings as well as with external partners
  • Record detailed experimental procedures in laboratory notebooks and controlled documents

Qualifications
  • Ph.D. degree in molecular biology or related fields plus 5+ years of analytical development experience. Industrial experience is desirable.
  • Expertise in CRISPR-Cas genome editing and molecular and genomic assays for characterization is required.
  • Experience in NGS methodologies is preferred; experience in Nanopore platforms a plus.
  • Experience in managing the team and projects is preferred.
  • Experience in lab automation is preferable.
  • Experience in bioinformatics, NGS data analysis, and scientific programming in data analysis tools, e.g. Python, R, ImageJ, JMP, is a plus.
  • Desire to understand the fundamental aspect of technologies, and the ability to identify creative solutions to overcome current limitations.
  • Ability to design, implement, analyze, and present experiments to demonstrate feasibility of new methods and efficiently move products through pipeline
  • Self-motivated, strong problem-solving ability, organizational skills, and attention to details
  • Comfortable in a fast-paced environment and able to adjust workload based upon changing priorities.
  • Excellent communication and presentation skills.

Working Conditions and Physical Requirements
  • Will require working with blood and cell lines of human and animal origin
  • Will require working with hazardous materials
  • 100% on-site work at corporate headquarters and research facilities in San Diego, CA
  • Occasional evening and weekend work will be required

The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.

About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.

Company

Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s effector cell pipeline includes multiplexed-engineered, iPSC-derived natural killer (NK) cell and T-cell product candidates, which incorporate novel synthetic controls of cell function, such as chimeric antigen receptors (CARs) to target tumor-associated antigens and are intended to deliver multiple mechanisms of therapeutic importance to patients including in combination with well-established cancer therapies. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit www.fatetherapeutics.com.

Company info
Website
Phone
858.875.1800
Location
12278 Scripps Summit Drive
San Diego
California
92131
United States

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