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Imaging Scientist and Biophysicist

Frederick National Laboratory for Cancer Research
Frederick, MD
Start date
Aug 7, 2022

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Imaging Scientist and Biophysicist

Job ID: req2779
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.


The Imaging Scientist and Biophysicist will:

  • Work closely with a highly collaborative multidisciplinary team of biochemists, biophysicists, computational scientists, and structural biologists at the NCI RAS Initiative to investigate the membrane interactions of RAS and RAS Effectors
  • Elucidate the properties of these membrane interactions, including their order and kinetics, to gain an improved understanding of their role in RAS biology and potential for drug discovery
  • Independently develop and execute advanced imaging and biophysical experiments. Collaborate with our DOE partners to inform their computational simulations.  Test and validate hypotheses generated by the MD simulations.
  • Analyze data with sophisticated image analysis tools.
  • Present research findings within the RAS Initiative and at scientific conferences, and publish findings in peer reviewed journals
  • Mentor junior scientists


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a (CHEA) Ph.D. degree from an accredited college/university in biochemistry, biophysics, or structural biology.  Foreign degrees must be evaluated for U.S. equivalency
  • First author publications
  • Knowledge of or experience relevant to characterizing RAS in membranes
  • Ability to independently design and execute multiple scientific projects
  • Ability to follow and apply standard laboratory production protocols and procedures
  • Ability to obtain and maintain a security clearance 


Candidates with these desired skills will be given preferential consideration:

  • Expertise in imaging and biophysical analysis of membrane proteins and complexes
  • Experience with confocal, Fluoresce Lifetime Imaging, Fluorescence Correlation Spectroscopy, Single Particle Tracking, Diffusion. 
  • Experience with super-resolution microscopy. 
  • Advanced knowledge of image analysis and analysis platforms, such as Matlab, ImageJ, Python.
  • Understanding or experience with MD simulations and supercomputing. 
  • Membrane biology background
  • Experience in biochemical and biophysical techniques (e.g. SPR, ITC, FRET, HTRF) for characterization of protein-protein interactions
  • Experience with the RAS pathway or similar signal transduction pathways
  • Capacity to communicate effectively orally and in writing


  • This position is subject to working with or have potential for exposure to infectious material, requiring
    medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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8560 Progress Drive
United States
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