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Scientist - Computational Genomics

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, New York
Start date
Aug 6, 2022

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Discipline
Science/R&D, Biotechnology, Genomics
Required Education
Masters Degree/MBA
Position Type
Full time
Hotbed
Pharm Country, Best Places to Work
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Job Details

We are seeking an Scientist, Computational Genomics that can help with the analysis and interpretation of millions of genotyped and sequenced humans, with a specific focus on ensuring we create and deploy premier software tools and pipelines that can operate on large-scale genetic and multi-omics datasets. For the Regeneron Genetics Center to generate the knowledge that will enable us to deliver better medicines to the patients who need them, we need to enable many scientists to productively generate and interact with results derived from 1,000,000s of sequenced individuals. 

A typical day may include:

  • Create novel, optimized, production-level pipelines for performing many aspects of multi-omics data processing and analysis.
  • Build tools and run computational NGS data analyses; including large scale genome-wide association testing and transcriptomics data analysis.
  • Maintain expertise in innovative data science and computational genomics methods, including benchmarking and testing these methods in a cloud-based (AWS, DNAnexus) environment.
  • Perform quality control analyses on new large-scale genomic, transcriptomic, proteomic, and phenotypic datasets, and providing summaries and visualizations of these steps.
  • Develop scalable, portable, unit testable code, and performing code review for efficiency and correctness.

This role could be for you if you:

  • Have a strong background in a variety of areas spanning bioinformatics, computer science, and genomics
  • Have a consistent record of implementing scalable software tools and workflows and in a cloud-based computing environment (AWS, DNAnexus, GCP)
  • Are skilled at working on a Linux/UNIX command line and can develop code in a high-level programming language like Python or C++
  • Have experience using a workflow language (e.g WDL, CWL, Nextflow) and software containerization (Docker)
  • Are familiar with many standard bioinformatics tools (e.g. PLINK2, HTSlib, tabix, VCFtools, Picard) and data formats (e.g. VCF, BED, BGEN)
  • Enjoy generating novel visualizations of datasets and QC metrics using R/ggplot2 or Pandas/matplotlib.
  • Have a familiarity with current standard methodologies and state-of-the art techniques across many areas of NGS data analysis, from variant calling to genetic association testing.
  • Can effectively communicate methods and present code to a variety of technical audiences.
  • Enjoy working in a highly interactive environment with a diverse team of colleagues.

To be considered for this role, you must at least have a master’s degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field with minimum 4 years relevant experience in Biotechnology or Computational Biology. A doctorate degree in Computer Science, Bioinformatics, Biomedical Engineering, or related field is preferred. Expertise in designing and implementing tools and pipelines that are well documented. Experience using many innovative bioinformatics tools and data formats. You should have experience contributing to the development of open-source bioinformatics tools or pipelines using standard methodologies in version control. Some previous experience with small web application development, preferred.

#RGCAG

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Find Us
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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