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Research Associate / Associate Scientist, Antibody Phage Display

Employer
Alloy Therapeutics
Location
Waltham, MA
Start date
Aug 6, 2022

View more

Discipline
Regulatory, Science/R&D, Biotechnology, Research
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown

Research Associate / Associate Scientist, Antibody Phage Display – Waltham, MA

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About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners across academia, biotech, and the largest biopharma, Alloy democratizes access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. Alloy’s foundational technology, the ATX-Gx™️, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Alloy is a leader in bispecific antibody discovery and engineering services, utilizing its proprietary ATX-CLC common light chain platform integrating novel transgenic mice and phage display. DeepImmune™️ integrates Alloy's full complement of proprietary in vivo, in vitro, and in silico discovery and optimization technologies into one comprehensive offering for fully human antibody, bispecific, and TCR discovery. DeepImmune is also available for royalty-free access as part of Alloy’s novel Innovation Subscription model. Alloy is headquartered in Boston, MA with labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. As a reflection of Alloy’s relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

 

About Research Associate or Associate Scientist – Waltham, MA

Our Alloy Discovery Services (ADS) group is looking for a Research Associate or Associate Scientist to join our team in Waltham, Massachusetts. The position will report directly to our Head of In Vitro Discovery and work with our Antibody Discovery Services team to support the discovery of antibody-based therapeutics and help strengthen and develop our internal platform technologies at Alloy. You will be using the latest technologies in molecular biology and antibody phage display for the ultimate goal of making better medicines together with our collaborators.

 

Principal Responsibilities

  • Construct antibody phage libraries by performing recombinant DNA activities, including cloning (Gibson Assembly, PCR, Vector Digestion)
  • Analyze DNA sequencing results to validate antibody phage libraries and to identify unique antibodies isolated from panned libraries
  • Perform phage panning, purify phage, and generate purified monoclonal Fabs
  • Determine antibody specificity for targets using ELISA, Octet, and flow cytometry
  • Utilize high-throughput methodology and automation workflows
  • Maintain organized electronic Lab Notebook & utilize electronic LIMs system for sample tracking
  • Be generous when others are needy, greedy, or fearful

 

Required Qualifications and Skills

  • MS with 1+ year or BS/BA with 2+ years of research experience working with recombinant DNA and proteins in support of biologics discovery
  • BA/BS/MS in an appropriate scientific discipline (Immunology, Biochemistry, Cellular or Molecular biology)
  • Self-starter, self-motivated, and willing to learn and grow in a dynamic team setting
  • An independent sense of urgency, persistence, and integrity

 

Benefits Include 

  • Competitive base salary based on the position and your experience level
  • Significant opportunities for career advancement and mentorship inside Alloy, through our affiliated venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
  • Generous equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental, and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support over $40,000, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development, and others

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