We are seeking a highly motivated and accomplished investigative scientist to join our team in Global Discovery, Investigative & Translational Sciences in Drug Safety Research and Development, La Jolla CA. The successful candidate will have the opportunity to work jointly in both Translational Omics and Mechanistic Toxicology laboratories. You will have the opportunity to test a hypothesis using state-of-the-art Translational Omics platforms to discover and validate small and large molecules (RNAs, proteins, metabolites, lipids, etc.) as safety and/or disease monitoring biomarkers. As part of the mechanistic Toxicology group, you will be able to design and carry out investigative studies to explore underlying mechanisms for toxicity findings to advance molecules in preclinical and clinical development. We are seeking an individual contributor with strong critical thinking skills and a track record of Translational Omics and mechanistic investigations using cellular and molecular biology approaches. The successful candidate will have a strong background in state-of-the-art Translational Omics platforms, novel in vitro model development, fit-for-purpose assay design, and hypothesis-driven mechanistic research. This joint position will provide enhanced professional development with cross-functional team training opportunities.
Use cutting-edge methodology/technology to discover, develop, validate, and translate novel mechanistic multiparametric biomarker panels to understand phenotypic safety and pharmacology.
Leverage understanding of biological pathways and disease pathogenesis to create mechanistic insights from the analysis of integrated Translational Omics data and investigative research.
Participate in immunophenotyping work using multi-color flow cytometry to support the evaluation of mechanisms of toxicity Independently generates high-quality laboratory-based investigative data to support portfolio progression and/or mechanistic understanding of toxicity findings
Participate in issue management teams, work cross-functional lines collaboratively as part of a global multi-disciplinary team
Develops novel in vitro models and fit for purpose in vitro or in vivo endpoints
Cross-trains other Translational Omics and/or investigative toxicology colleagues
Communicates experimental findings accurately and concisely in both oral and written formats; analyzes, documents, and reports laboratory data in accordance with company standards and procedures.
Degree in Biology, Chemistry, Pharmacology, Toxicology, Biochemistry, Cell Biology, or Molecular Biology is required.
Bachelor's with 6+ years of full-time laboratory experience or master’s with 4+ years of research/pharma experience.
Expertise in multi-color flow cytometry
Expertise with the mechanistic investigation of toxicity findings and fit-for-purpose biomarker development/evaluation, with a record of peer-reviewed publications and/or scientific presentations related to biological sciences.
Hands-on experience in standard investigative laboratory capabilities, including cellular (primary cell culture), biochemical (enzymatic, plate-based assays), RNA-based platforms, and molecular (PCR, western blot) techniques.
Strong attention to detail, communication, and organization skills. Team player with solid collaboration skills. Thrives in a fast-paced, dynamic, and mission-driven atmosphere.
Bachelor's with 6+ years of full-time laboratory experience or master’s with 4+ years of research/pharma experience
Hands-on experience with multiplex ligand-binding assay platforms (e.g., MSD, Quanterix, Bioplex/Luminex, Ella)
Expertise in targeted gene modification techniques (e.g., siRNA, CRISPR)
Experience in therapeutic areas such as Oncology, Inflammation/immunology, and rare diseases.
Lifting (reagent bottles, etc.), sitting, standing, walking, bending, ability to perform mathematical calculations, and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development