SCIENTIST I, CELL BIOLOGY
We are looking for a Scientist I with expertise in cell biology, assay development, and a passion to understand mechanisms of disease. The successful candidate will join a multi-disciplinary team and support our drug discovery effort by investigating cellular models of human hemoglobinopathies to elucidate the mechanisms underlying various disease manifestations. He or she will be a key contributor to the build out of our in-house functional genomics platform through developing and executing bespoke cell-based assays to enable genome-wide target identification and validation. The candidate will play a key strategic role in identifying and applying techniques and methods to profile the effect of genomic and small-molecule agents in cellular models of disease, supporting early research and drug discovery programs. Major responsibilities will include independent, hands-on experimental work to guide ongoing and novel drug discovery efforts. The ideal candidate will be highly motivated, detail-oriented, working autonomously with a variety of techniques, and comfortable presenting results to cross-functional teams.
Essential Duties and Responsibilities:
- Independently plan, execute, and analyze experiments
- Investigate cellular models of disease to drive early target and drug discovery projects
- Leverage cell-based assays to evaluate target and drug candidates
- Establish novel cell models and assays to suit research needs
- PhD in Cell Biology, Molecular Biology or a related field with 2+ years of related experience, or BS or MS with 4+ years of laboratory experience
- Deep experience in mammalian cell culture (adherent and suspension cells), fluorescence-activated cell sorting (FACS) and microscopy
- Demonstrated ability to develop robust and scalable assays using cell-based models
- Experience in CRISPR/Cas9 genome-wide screening and genome editing to investigate disease-relevant mechanistic biology and/or target identification and validation
- Special consideration given for candidates with expertise in erythroid biology or differentiation of iPSC/CD34+ cell models
- Hands-on experience with genomics technologies such as transcriptomics, epigenomics, proteomics, and/or scRNA-seq is a plus
- Ability to work independently as well as contribute actively to an integrated team
- Demonstrated ability to deliver solutions by systematic troubleshooting, creative/critical thinking, high degree of accuracy and attention to details
- Excellent organizational and communication skills (oral, written, presentation)
Fit with GBT culture:
- Ability to build strong relationships with co-workers of various backgrounds and expertise
- Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
- Values-based leadership consistent with GBT's Core Values
- Excitement about the vision and mission of GBT
NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities. The Company requires all employees working in its facilities (including attending in-person meetings and events) to be fully vaccinated from COVID-19 (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for a disability/medical condition or sincerely-held religious belief, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. This position requires you to maintain a fully-vaccinated status against COVID-19, subject to reasonable accommodations required by applicable law. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.