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Senior Maintenance & Operations Technician III

Astellas Pharma US, Inc.
South San Francisco, California
Start date
Aug 4, 2022

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About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website:

About Astellas

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. For more information, please visit our website at

Our Values:

  • Be BOLD (Find a Way)

  • Care Deeply -- for our patients, each other and our work

  • #GSD (Get Stuff Done)

What is the catalyst for you in your professional career? Are you ready to be a part of a bold, innovative company, to make a change and to make a difference? Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us and be a part of our journey.

The Role

Reporting to the Facilities Maintenance & Operations Supervisor, the Senior Maintenance & Operations Technician will be part of the Facilities Operations department supporting Manufacturing, R&D, and administrative facilities. This position will be part of a small team that ensures proper operation of utility system, process equipment, and site services using approved procedures. The role is primarily located in South San Francisco, CA .

Primary Responsibilities

  • Create and complete work orders using a CMMS to maintain utility systems, facilities, and process equipment. Ensure maintenance records and service reports follow cGxP.

  • Ensure safe and compliant day-to-day operations of utility and support systems including use of BAS & EMS. Ensure facilities are fit for use by maintaining cGMP and safety standards.

  • Provide emergency response to alarms, lead troubleshooting and recovery efforts.

  • Complete required training and maintain accurate training records.

  • Document technical work performed accurately and completely.

  • Read and interpret blueprints, schematics, equipment/service manuals, logic flow diagrams, and work orders to perform required maintenance and troubleshooting.

  • Provide input for creation and revision of maintenance plans, spare parts inventory, and SOPs.

  • Partner with internal customers and suppliers, colleagues and support services to achieve department goals.

  • Understand and adhere to internal and external regulations, procedures & policies.

  • Effectively communicate safety, quality, technical and training issues to team. Enforce and follow all safety rules and regulations.

  • Interact with stake-holders, and vendors.

About you

Must Have/Required

  • High School diploma or GED with 8+ years of maintenance and operating experience in a GxP environment or comparable field or 4+ years of experience with applicable degree/certification/license (e.g., plumber, electrician, HVAC technician).

  • 4+ years of experience maintaining and operating utility plant systems, HVAC&R (refrigeration, boilers, air handlers) systems, compressed air and gas systems, BAS, and purified water systems.

  • Strong skills troubleshooting electro-mechanical systems, performing repair or replacement of parts, testing and making adjustments using approved procedures or technical experience when no procedure is available.

  • Demonstrated experience reading and interpreting blueprints, schematics, equipment/service manuals, logic flow diagrams, and work orders and have successfully performed required maintenance and troubleshooting.

  • Excellent documentation skills

  • Strong oral and written communications skills.

  • Demonstrated experience using a variety of hand and power tools, electric meters, ladders, and safety equipment in performing duties.

  • Occasionally required to stand up to 6 hours a day. While performing the duties of this job, the employee is frequently required to reach with hands and arms, stand; walk; talk or hear; and use hands to finger, handle, feel or operate objects, tools, or controls. The employee is occasionally required to sit; climb or balance; stoop, kneel, crouch or crawl, and lift 50 lbs.

  • Knowledge of industrial air compressors and supporting equipment including distribution.

  • Strong GxP knowledge and understanding.

  • Team player with a successful history of working with other internal departments and external vendors.

  • This is a 4x10 Swing shift schedule (3:30pm-2:00am) and will be assigned to Sunday-Wednesday or Wednesday-Saturday. The first 3 months will be 4x10 Day shift schedule (6:00am-4:30pm) for training. The following 3 to 9 months will be 4x10 modified Day shift schedule (11:30am-10:00pm).

  • Proficiency with MS Word, Excel, Outlook, and PowerPoint.

  • Flexible and able to excel and adapt to rapidly changing situations.

  • Self-motivated and have the ability to handle multiple jobs with minimal supervision.

  • Models our Core Values: Be Bold, Care Deeply, #GetStuffDone -- is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted

May Have/Preferred

  • Experience in a small company and high growth, fast-paced environment

  • Completion of a craft apprenticeship.

  • Working experience with a CMMS, planning and scheduling.

  • Experience in maintaining adequate on-hand spare parts inventory or lead-time system in place to support responsible equipment.

  • Understanding of PLC and BAS programing.

  • Previous experience with a facility start-up.


  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

Category Facilities, Utilities & Maintenance

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans

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