Senior Principal Scientist, Translational Clinical Biomarker Pathology Expert

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science.In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies

We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA. This non-lab-based individual will be responsible for working with internal and external labs on assay development, validation and clinical sample review to support translational biomarker strategies and plans.

Position Responsibilities:

In this role as Senior Principal Scientist, Translational Clinical Biomarker Pathology Expert, within the TME TRC Translational Development team, the ideal candidate:

• Applies scientific, technical and functional expertise in pathology as a subject matter expert and partner to Translational Development Biomarker Leads for multiple oncology/immuno-oncology programs with a strong focus on tumor microenvironment related biomarkers

• Serves in an individual contributor role (non-lab based) with projects that contribute to the overall group/programs with relevant pathology assays for First in Human through Proof of Concept clinical trials (e.g. pharmacodynamic, target engagement, mechanism of action and/or potential patient selection biomarkers)

• Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.

• Designs assay development and validation plans, develops and implements approaches for review of clinical sample images, data and image analysis algorithms/analyses

• Closely collaborates with internal pathology colleagues, and with internal and external partners, as relevant, to ensure confidence in data in compliance with relevant BMS guidance and policies

• Develops solutions and courses of action for Translational Development Biomarker Lead partners and senior staff, including identification of risks and risk mitigations

• Provides recommendations around technologies, reagents, troubleshooting, controls, quality, data analysis and platforms based on the intended use of the assays in clinical trials in context of program strategies, relevant biology and assay data

• Supports, drafts and/or reviews relevant internal and external documents (e.g. scopes of work, validation reports, study reports, lab manuals, etc.)

• Participates in vendor discussions, translational subteams and other relevant cross-functional collaboration meetings

• Provides sample collection and logistics expertise in collaboration with Translational Biomarker lead and global biospecimen lead

• Collaborates with translational project management and planning team and Translational Biomarker Lead to monitor and track assay status, timelines and deliverables

• Definition of data transfer variables for data agreements and data transfer pathways in collaboration with relevant informatics and biostatistics teams

• Share expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization

Requirements:

• Ph.D, MD or DVM, or their foreign equivalents with 8+ years relevant work experience, preferably in industry

• Note this role is not lab-based, but is located in Redwood City, CA, and requires significant prior experience in clinical assay development / validation and clinical trial sample analysis, preferably in pharma, biotech, contract research organization (CRO), specialty testing lab or clinical lab setting

• Expertise in histopathology and pathology assays relevant to the tumor microenvironment and:

  • Methods such as IHC (monoplex, duplex, triplex, etc.), multiplex immunofluorescence, and ISH

  • Platforms such as Dako, Ventana and Leica

  • Familiarity with relevant whole slide scanning, image analysis (including spatial profiling), algorithm development, data processing

  • Familiarity with analysis packages such as Halo, VisioPharm and Aperio

  • Definition of regions of interest / cell types of interest for relevant analyses

• Ability to effectively cooperate and partner with external providers and others within BMS

• Experience working with CROs and specialty testing laboratories

• Demonstrated experience in the appropriate application of various scientific technologies into translational strategies in clinical sample analysis in various stages of clinical development.

• Experienced in working as a topic expert, outside of a traditional functional environment, in a team unified around assets, and with internal and external stakeholders

• Excellent communication skills and comfortable working in a fast-paced environment where speed is paramount

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Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

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