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Scientist I, RAS Mass Spectrometry

Frederick National Laboratory for Cancer Research
Frederick, MD
Start date
Aug 3, 2022

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Scientist I, RAS Mass Spectrometry

Job ID: req2516
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: ATRF: Other
Location: 8560 Progress Drive, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

 Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.


  • Conduct a range of independent and collaborative NCI RAS Initiative projects encompassing bottom-up, top-down, native, and quantitative proteomic applications
  • Perform method development for proteomic analysis of unique and challenging targets
  • Support assay development for protein and PTM quantitation by peptide or proteoform reaction monitoring (PRM, PfRM)
  • Assist with the daily operation and routine maintenance of three Orbitrap-based LC-MS platforms (Exactive Plus EMR, Orbitrap Fusion Lumos, Exploris 480)
  • Attend project meetings, provide updates to collaborators, contribute to publications in leading journals, and present research findings at conferences or symposia


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in Chemistry, Biochemistry, Molecular Biology, or a related field or eight (8) years of related experience. Foreign degrees must be evaluated for U.S. equivalency
  • No experience necessary with doctoral degree
  • Knowledge or experience in sample preparation, data acquisition, and data analysis for quantitative proteomics and/or top-down proteomics (with accompanying publication record)
  • Demonstrated experience in operating and maintaining Orbitrap-based instruments
  • Demonstrated ability to independently lead projects, balance changing priorities, collaborate with a team, and perform troubleshooting to ensure timely project completion
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Prior experience in top-down proteomic applications (global and targeted), crosslinking mass spectrometry for structural biology applications, or native mass spectrometry of membrane protein complexes
  • Prior experience in protein purification, protein biochemistry, and standard molecular biology workflows


  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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8560 Progress Drive
United States
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