Scientist II, Molecular Biology

Summary

As a member of the Core Technology Research and Development team the Scientist II will support cell and gene therapy programs. The incumbent will be involved in development of assays, discovery and development of antibodies or other proteins for cell therapy projects, development and/or characterization of nucleases for genome editing, genetic characterization of gene-edited cells.

**Please note, Precision BioSciences mandates COVID-19 vaccination of all employees. Accommodations may be made in accordance with applicable law.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position.  This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

• Development of assays
• Generation of expression constructs
• Phage display selection of antibodies or other proteins and their characterization
• Optimization of selected proteins via affinity maturation and directed engineering
• Rational protein engineering and characterization
• Characterization of nucleases
• Characterization of proteins by ELISA and functional assays
• Genetic analysis of gene-edited cells
• Assistance with any other related projects if needed

Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Required:

• PhD in molecular biology, genetics, biochemistry, immunology, or related field, with 2+ years of experience, MS in molecular biology, genetics, biochemistry, immunology, or related field with 6+ years related academic or industry experience or equivalent combination of education and experience 
• Strong molecular biology skills; experience with PCR amplification, quantitative PCR and/or digital PCR, cloning, genomic DNA manipulations/analysis, DNA sequencing analysis
• Protein engineering and characterization experience, ELISA, small scale protein expression/purification
• Ability to work independently and in team environment
• Ability and desire to manage other researchers
• Strong communication skills, including written and verbal reporting to supervisor, team, company, and at conferences

Preferred:

• Practical knowledge of phage display or any other selection methods
• Construction/cloning of combinatorial protein libraries
• Antibody development/characterization
• Experience in the development of T-cell therapies (such as CAR-T or TCR) or immunotherapies
• Experience in the development of gene editing therapies

Travel Requirements

• Minimal travel is expected for this position.

Location

• This is an office-based position located at the main headquarters in downtown Durham, NC.

Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS® genome editing platform. This isn’t just a statement supporting the products that we’re developing – it’s a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs.  For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.