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Production Research Associate, Neuroscience In Vitro

Employer
Recursion
Location
Salt Lake City, Utah, United States
Start date
Jul 29, 2022

View more

Discipline
Manufacturing & Production, Regulatory, Science/R&D, Pathology
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Everything we do is in pursuit of changing lives.

Recursion is a clinical-stage biotechnology company decoding biology by integrating technological innovations across biology, chemistry, automation, data science, and engineering. Our goal is to radically improve the lives of patients and industrialize drug discovery. Central to our mission is the Recursion Operating System, which combines an advanced infrastructure layer to generate what we believe is one of the world’s largest and fastest-growing proprietary biological and chemical datasets. We combine that with the Recursion Map, a suite of custom software, algorithms, and machine learning tools that we use to explore foundational biology unconstrained by human bias and navigate to new biological insights. We are a biotechnology company scaling more like a technology company.

We have created a highly-scalable, automated laboratory robotics workflow that enables us to conduct up to 1.5 million experiments each week for up to 50 weeks per year with only a small team overseeing our processes at any given time. Every step of every experiment is monitored and measured, creating a comprehensive layer of meta-data that is critical for interpretation and analysis in our Recursion Map.

While we are united in a common mission, Decoding Biology to Radically Improve Lives, our greatest strength lies in our differences: expertise, gender, race, disciplines, experience and perspectives. Deliberately building and cultivating this culture is critical to achieving our audacious goals.

Recursion Pharmaceuticals is at the forefront of re-imagining drug discovery through the integration of automated cell biology, generation of high-dimensional and diverse data sets, and sophisticated analytics. We are seeking a Production Research Associate to work on human iPSC derived neural cell types, molecular and functional characterizations, and developing relevant disease models.

The Impact You’ll Make

  • Enable Recursion to build Maps of Biology by isolating, differentiating, expanding, and banking iPSC-derived neuronal cell types for use in screens that incorporate CRISPR editing and gene delivery methods at scale
  • Provide provide high-quality, consistent cells for Recursion’s High Throughput Screening and utilize available in vitro cell culture tools that allow for the loss of function, inducible and stable gain of function in the iPSC-neuronal human cell background and those cells that interact with neuronal cells, iPSC-microglia
  • Bank cells derived from the diseased patient population of interest that have been altered for potency (iPSC) and provide for comparable lot productions of cells differentiated from these intermediates
  • Train team members to perform newly developed methods for scale to enable 100’s of 1536 well microplates screened per week
  • Collaborate with data scientists, computational biologists, chemists, and clinical strategists across the organization to develop Recursion's data-to-therapeutic pipeline to discover new impactful medicines and ultimately serve patients

***This position may require you to work 2 weekend days per month, which in turn you will have 2 flex days off in the following weeks.***

The Team You’ll Join 

You'll be a member of our highly productive Neuroscience team as well as our High-throughput Tissue Culture Core Facility Team (HTS TC). You will be working on the utilization of human pluripotent stem cells (hPSCs) to model neurodegenerative diseases. You will use state-of the art differentiation technology to generate advanced disease models at large scale. Your work will be highly collaborative, interactive, and multithreaded. As a Production Research Associate, you will provide high-quality, consistent cells for Recursion’s High Throughput Screening (HTS) and Biology efforts in support of drug discovery and development. The HTS TC Core is involved in the translation, scale and banking of critical cell culture resources, improving existing operations with the validation of novel in vitro culture systems, enabling innovative gene delivery and gene expression systems while monitoring the logistics and specifications applied to individual productions. 

You will integrate with our neuroscience team to work  on novel in vitro assays for the world's leading company in AI-guided drug discovery. You will interact closely with our Biology Team to develop relevant assays, with our High-throughput Tissue Culture Core Facility Team (HTS TC) within Recursion’s Core Operations Department to enable scale, and with our computational biology groups to enable AI-driven drug discovery and therapeutics development.

The Experience You’ll Need

  • BS with 1+ years  in-vitro cell culture production experience; OR MS with  in-vitro cell culture production experience
  • Demonstrated and/or practiced aseptic technique
  • Experience with the manipulation of primary or immortalized mammalian cells in culture
  • Experience with cell culture techniques and cell-based assays using primary or iPSC derived neurons, astrocytes, and/or microglia preferred
  • Ability to apply quality control measures of success across intermediate and differentiated cell populations
  • A passion for working in a fast-paced environment where you’ll leverage creativity and independent thinking when deriving, expanding, banking and genetically perturbing challenging human cell types
  • Demonstrated capacity to independently manage and coordinate scientific projects
  • Experience leading projects and mentoring/training of others
  • Efficient and effective communication of research findings and interpretation in written and verbal form
  • Strong interpersonal skills with the desire to work in a team that trusts and supports each other

#LI-LM1

The Values That We Hope You Share:

  • We Care: We care about our drug candidates, our Recursionauts, their families, each other, our communities, the patients we aim to serve and their loved ones. We also care about our work.
  • We Learn: Learning from the diverse perspectives of our fellow Recursionauts, and from failure, is an essential part of how we make progress.
  • We Deliver: We are unapologetic that our expectations for delivery are extraordinarily high. There is urgency to our existence: we sprint at maximum engagement, making time and space to recover. 
  • Act Boldly with Integrity: No company changes the world or reinvents an industry without being bold. It must be balanced; not by timidity, but by doing the right thing even when no one is looking.
  • We are One Recursion: We operate with a 'company first, team second' mentality. Our success comes from working as one interdisciplinary team.

Recursion spends time and energy connecting every aspect of work to these values. They aren’t static, but regularly discussed and questioned because we make decisions rooted in those values in our day-to-day work. You can read more about our values and how we live them every day here.

Recursion requires all employees to be fully vaccinated for COVID-19 prior to their first date of employment.

More About Recursion 

Central to our mission is the Recursion Operating System, or Recursion OS, that combines an advanced infrastructure layer to generate what we believe is one of the world’s largest and fastest-growing proprietary biological and chemical datasets and the Recursion Map, a suite of custom software, algorithms, and machine learning tools that we use to explore foundational biology unconstrained by human bias and navigate to new biological insights which may accelerate our programs. We are a biotechnology company scaling more like a technology company. Recursion is proudly headquartered in Salt Lake City. 

Recursion is an Equal Opportunity Employer that values diversity and inclusion.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation. 

Company

Recursion is a clinical-stage biotechnology company decoding biology by integrating technological innovations across biology, chemistry, automation, data science and engineering to radically improve the lives of patients and industrialize drug discovery. Our team is working to solve some of the hardest, most meaningful problems facing human health today. Come join us in our mission to decode biology to radically improve lives, while doing the most impactful work of your life.

Find Us
Website
Phone
801-587-1629
Location
383 S. Colorow Drive
Salt Lake City
Utah
84108
United States
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