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Senior Bioprocess Engineer

ZymoChem, Inc.
San Leandro, CA
Start date
Jul 28, 2022
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About ZymoChem

ZymoChem is re-imagining how to make some of our favorite everyday products without polluting the planet. Motivated by the enormous carbon footprint and vast amount of trash from the fossil-based materials produced by century-old technologies of the ‘traditional’ chemicals industry, ZymoChem’s mission is to create plant-based, hero materials that enable a sustainable future. We are realizing this vision by pioneering low-cost fermentation-based production of chemicals coupled with advanced materials development technologies. 

ZymoChem has raised >$18 million to-date that includes funding from premier domestic & international venture capital firms, multiple government awards – most recently two ARPA-E awards – and partnerships with world-leading chemicals companies. Tripling in team size in 2021, we are still rapidly growing and filling multiple roles ( We seek candidates who are motivated by science & innovation and have a passion to push the boundaries of materials performance. We are collaborative, multidisciplinary, and relentlessly committed to creating a chemicals & materials industry in tune with the 21st century. If this sounds exciting, we want to hear from you. 

The Opportunity

ZymoChem is seeking a Senior Bioprocess Engineer to develop & scale-up the company’s fast-paced, milestone-driven proprietary carbon conserving bioprocesses. This role is a career-defining opportunity to gain diverse experiences while accelerating the scale-up of downstream product recovery processes from the benchtop to pilot scale, and ultimately to production levels. The individual will have opportunities for consistent multi-disciplinary collaborations with internal Fermentation, Analytics, and Materials Development groups, as well as with the company’s external partners. As part of the larger Bioprocess Team, the Senior Bioprocess Engineer will have the potential to support the execution of bench to pilot scale fermentations and advise on methods to streamline the overall process. Adhering to the company philosophy of prioritizing, streamlining, and managing projects & product portfolios in accordance with company milestones, customer timelines, and product specifications, the Senior Bioprocess Engineer will have opportunities to work with the department lead towards timely planning and high-quality execution of KPIs, along with managing functionally integrated project timelines and work plans.


♦ Design commercially-scalable processes for the recovery and purification of microbial fermentation-based products

♦ Lead the hands-on setup and execution of bench-scale downstream processing (DSP) unit operations for both proof-of-concept experiments and benchmarking studies to meet project milestones aimed at achieving product yield, purity and performance at industrial specifications

♦ Routinely interface with and provide support to the Fermentation Group in executing experiments at bench-to-pilot scale

♦ Supports the team in data analysis and DOEs

♦ Developing and executing sampling and sample processing schemes, in addition to establishing new analytical approaches in collaboration with our Analytical and Materials Development groups for evaluating process streams

♦ Collaborate with CMO partners and lead DSP scale-up endeavors

♦ Lead and contribute to project management efforts for intra- and cross- functional projects, as well as with external partners, including CMOs and customers

♦ Manage the expansion of the Bioprocess Development group’s capabilities by exploring new technologies and strategies to improve bioproduct recovery & purification and accelerate scale-up efforts

♦ Contribute to the development of ZymoChem’s IP strategy & portfolio toward expanding the company’s competitive position

♦ Interface with the company’s data management system to record DSP-based data and implement statistical analyses on large data sets

♦ Support the maintenance of the company’s product recovery & purification technologies via hands-on equipment troubleshooting & repair


♦ PhD or MS in (Bio)chemical Engineering, Chemistry, Process Engineering, Material Science, or a related discipline with 2- 6 year of industrial/startup experience working directly with bench and pilot-scale bioprocess development

♦ Extensive and in-depth experience in data analysis and using statistical softwares like JMP (or comparable) is a must for this role

♦ Hands-on expertise with chemical separations equipment and related analytical devices is a requirement

♦ Experience with microbiology/fermentations, bioreactors and bioprocess-related unit operations

♦ Solid fundamental knowledge of biochemical & process engineering principles including mass balance & transport, reactor design, fluid dynamics, and process control

♦ Prior industrial work with modeling software (ASPEN, SuperPro) and/or building computational models; familiarity with scripting tools such as Python and R is a plus

♦ Strong aptitude for hands-on work with equipment along with a rigorous attention to details with experimental design, execution, and recordkeeping

♦ Excellent time management skills, effective multitasking, and an adept ability to improvise work plans while maintaining efficiency. Prior exposure to project management tools is highly desired 

Full-time opportunities at ZymoChem come with

    Competitive benefits package that includes medical, dental, and vision employee coverage, along with stock optionsOptional benefits including dependent coverage, FSA, HSA, commuter, and supplemental life insuranceFlexible time off policy with 15 days PTO and 10 paid company holidays per year

The company is headquartered in the east bay area of California, with its R&D facility located in San Leandro, CA.

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