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Senior Research Associate, Molecular Biology

Employer
DNA Script
Location
South San Francisco, CA
Start date
Jul 28, 2022

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Discipline
Regulatory, Science/R&D, Biology, Molecular Biology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay
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Job Details

DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system. 

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo. 

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges :

We are looking to assemble a team of best-in-class, innovative and passionately eager people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

Responsibilities:

  • Design and develop assays directed at qualifying DNA synthesis quality leveraging PCR and/or qPCR.
  • Contribute to/lead the design of synthesis controls which can be assayed within 24hours.
  • Carry out experiments and various tasks related to the validation of SYNTAX instrumentation.
  • Perform routine quality control tests of synthesized DNA: spectrophotometry, gel electrophoresis, fluorescence imaging, DNA quantitation, qPCR and NGS.
  • Perform reagents quality and stability studies as needed.
  • Prepare and revise the work instructions and reports as required.
  • Develop, optimize, validate, and troubleshoot analytical test methods.
  • Perform fluorescence labeling of DNA samples (end-labeling), order and maintain nucleotide solutions and precursors.
  • Design and perform experiments supporting the creation of application notes and marketing collateral.
  • Work closely with team members to improve quality and performance of the synthesis system
  • Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities

 

Required Qualifications:

  • Bachelor’s/Master’s degree in molecular biology, chemistry, biochemistry, or related field.
  • 2 to 4 years of experience working in an Academic research or Life Sciences R&D organization.
  • Knowledge of molecular biological techniques for handling and manipulating DNA samples.
  • Prior experience in qPCR, NGS library preparation, sequencing, and utilizing automated systems.
  • Strong documentation skills and ability to effectively communicate verbally and in writing, utilizing Word, PowerPoint, and Excel.
  • Demonstrated ability to work independently and take initiative in problem solving.
  • Proficient in data analysis and interpretation.

 

 

Ideal Candidate will have:

  • Strong analytical mindset, detail oriented, and adept using Microsoft Excel or other tools to communicate and present data.
  • Past experience involving primer, probe (Fluorescent label) design for qPCR.
  • Versatile and adaptable to new methods, technologies, and approaches.
  • Prior experience with library-preparation and next-generation sequencing.
  • Experience in high-throughput experimental formats, such as 96-well and 384 well-formats.
  • Relevant experience working in a GMP/GLP environment
  • Proactive, solutions-focused
  • Self-motivated and passionate.
  • Comfortable to work in a fast-paced work environment.

 

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q2 2022.

 

Company

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using a proprietary enzymatic technology. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of synthetic biology across diverse disciplines such as biopharma, sustainable chemistry and data storage. DNA Script’s first product will be a DNA printer. On course to hit the shelves in 2021, this benchtop instrument will enable researchers to target and program specific areas of the genome.

To date, DNA Script has raised over $100M of financing, mostly through leading investors such Casdin, Agilent, Danaher, LSP, Bpifrance, Illumina Ventures, Merck Ventures, Sofinnova Partners, Kurma Partners, Idinvest.

DNA Script has its research facility headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

We’re science-driven thinkers, makers, dreamers and do-ers. Our goal is to develop technology to accelerate advances in life sciences and health.

DNA Script is now moving to a new stage of development, i.e. commercialization. That’s why we are looking for new talents in different fields: R&D, manufacturing and supply chain, sales and marketing, industrial and IT engineering, etc.

If you are passionate about life sciences and their projects, curious, motivated, proactive and want to invest in a company with an innovative project, do not hesitate to send us your application!

Join DNA Script means :

  • Participate and bring to life a project that makes sense and will have a real impact on future generations
  • Be part of a strong scientific and technical environment: a technology that pushes the limits of what is today possible in the world of DNA synthesis. Collaborations with MIT, Harvard etc.
  • A scalable position: you will benefit from training, work on transversal projects, etc.
  • Discover different cultures because at DNA Script we come from all over the world.
  • Friday breakfast, afterworks and teambuildings frequently
  • A management with values Excellence, transparency and kindness, where the well-being is not just a promise! 

 

French office: 67 avenue de Fontainebleau, 94 270 Le Kremlin-Bicêtre

 

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Find Us
Website
Phone
650-457-0844
Location
650 Gateway Boulevard,
South San Francisco
CA
94080
United States
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