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Scientist I

Frederick National Laboratory for Cancer Research
Frederick, MD
Start date
Jul 28, 2022

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Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Scientist I

Job ID: req2877
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

The Frederick National Laboratory for Cancer Research (FNL) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors.  This open position in is ideally suited for a scientist who is more interested in applied Research & Development than in performing basic research. The selected candidate will join the Clinical PD Biomarkers program located at the NCI-Frederick campus. 

The Clinical PD Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the NCI. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. The program facilitates mechanistic evaluation of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to facilitate clinical entry, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue. The program operates a number of advanced, specialized instrumentation for measurement of multiplexed biomarkers, image analysis of tumor biopsies, circulating tumor cells, and activated T-cells for measuring drug effects in patients enrolled in phase 0 and 1 clinical trials.


  • Develop multiplex immunoassays of de novo pharmacodynamic biomarkers on Luminex platform, write “standard operating procedures” (SOPs), perform analytical validation of assays, process assay data using appropriate statistical methodologies and implement PD biomarker assays in preclinical and clinical studies
  • Independently perform complex assignments associated with all aspect of immunoassay development, validation, data analysis and implementation
  • Troubleshoot day-to-day activity on multiplex immunoassays to meet/ensure required performance
  • Design biomarker driven preclinical pharmacodynamic studies
  • Train lab personnel on techniques in multiplex immunoassay and perform SOP based inter-laboratory transfer of PD biomarker assays
  • Prepare and characterize reagents required for immunoassay development (antibody conjugates, calibrators, stabilizers etc.) to support Luminex assays for clinical and preclinical testing
  • Design and prepare quality control materials from tumor models, animal tissues and cancer cell lines and qualify them for biomarker assays
  • Prepare progress reports for management, maintain all work-related documentation and deliver accurate, traceable results to the program leaders


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university (according to CHEA) in a field relevant to biomedical research
  • Foreign degrees will be evaluated for U.S. equivalency
  • Experience in techniques used in immunoassay development such as SDS-PAGE, Western blotting, antibody characterization, conjugation of proteins, protein purification, and cell culture
  • Experience in preclinical pharmacodynamic biomarker analysis
  • Computer skills, knowledge about computer languages, ability to perform basic laboratory math including some knowledge of basic statistical methodologies
  • Able to independently design and conduct experiments, process quality control data, and process results into presentable scientific reports
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:  

  • Two (2) or more years of experience in immunoassay development and validation of biomarkers on Luminex platform
  • Demonstrated ability to independently design and conduct experiments, organize work, process experimental data, and generate appropriate reports / presentations
  • Demonstrated experience in monoclonal antibody development and protein chemistry 
  • Demonstrated experience in multiplex analytical methods and validation process
  • Knowledge of clinical trial designs and regulatory aspects
  • Experience in clinical specimen testing of tissues and cells
  • Possess skills in setting up, care and use of laboratory equipment (liquid handling systems and Luminex readers) and ability to improve a methodology
  • Ability to identify and trouble shoot multiplex immunoassay problems and take corrective actions


  • This position is subject to working with or have potential for exposure to animal(s)
    and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious
    material, requiring medical clearance and immunizations

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)



A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take



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