Senior Scientist, Therapeutics

About Earli 

The mission of the Biotechnology startup Earli Inc. is large and ambitious: to detect and then cure cancer at its earliest stages, effortlessly and pain free. In other words, ‘make cancer a benign experience’. The technology which grounds the company’s efforts ushers in a new era in “synthetic biomarkers” as a novel methodology to detect cancer and then subsequently localize and then treat the cancer.  The enabling technology utilizes “synthetic biomarkers” as a novel methodology to detect, localize and ultimately destroy cancer.   Founded by Sam Gambhir, Cyriac Roeding and David Suhy, the company is well funded by world-class entrepreneurs and venture capital firms. Earli, Inc. is currently based in Redwood City, California. 

Who You Are

• You share our same sense of dedication, scientific passion and entrepreneurial spirit 
• You work well in a fast-paced and extremely focused startup environment 
• You are not only smart, but clever and constantly think outside the box 
• You are able to make logical decisions in an instant when there is little time to evaluate 
• You are a natural communicator and relationship builder 
• You stay calm under high pressure and stress 
• You have the ability to multi-task in a serious way, with an extreme attention to detail 
• You become a representative of the core DNA of the company through who you are 

The Position

Earli, Inc. is currently seeking a highly motivated and committed Senior Scientist for our Therapeutics team.

Your Primary Responsibilities

Earli’s platform technology uses cancer-activated gene expression to usurp the dysregulated pathways that lead to malignancy.  As a scientist or senior scientist you will be leveraging this platform for the creation of novel therapeutic approaches to treat cancer.  Within this context, you will:

• Utilize a wide variety of cellular immunology and molecular immunology techniques to contribute to the identification and validation of therapeutic targets
• Design and execute strategies in preclinical models for the development of novel gene therapy and/or cell therapy agents for the treatment cancer
• Use immunology techniques including cytokine analysis, functional assays, imaging, and cell biology in order to ascertain mechanism of action
• Work with other team members to generate appropriate efficacy and safety data packages for the advancement of clinical candidates for regulatory submission.
• Document results and communicate findings to internal teams and to external partners 

Your Required Experience, Knowledge and Skill

• PhD in immunology, cell biology, or a related discipline.
• Minimum of 4+ years of industry experience developing gene therapy or cell therapy based approaches for the treatment of cancer
• Have an exceptionally strong background in immunology, cancer genetics, or cellular mechanisms of oncogenesis including a proficient understanding of the innate and adaptive immune response to cancer
• Must have technical expertise with in vitro cellular & molecular immunology assays
• Must be proficient with flow cytometry acquisition and analysis
• Hands-on molecular biology experience that includes DNA and RNA isolation, various cloning techniques & strategies, PCR, qPCR, and standard biochemical assays
• Previous experience with nucleic acid based expression approaches including viral and non-viral transductions methods as well as engineering cell lines for various readouts and functions is preferred
• Must be able to think outside of the box
• Ability to integrate and collaborate into a high achieving team environment
• Ability to handle multiple projects simultaneously and meet aggressive project timelines
• Exceptional verbal communication and scientific writing skills are required
• Desire to continue to continue in a laboratory focused role

If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background. 

We look forward to hearing from you!