We are currently searching for a Chemist to independently provide support services to satisfy the overall operational objectives of the National Institute of Mental Health. This is a full-time, on-site opportunity in Bethesda, MD.
Duties & Responsibilities
- Collaborate with staff on procedures used for the quantification of radioactive tracers and nonradioactive reagents for brain imaging in biological fluids and tissues of humans, nonhuman primates, rodents, and for in vitro ligand binding.
- Work with staff on the micro, accurate and precise analysis of plasma and other tissues radio metabolites.
- Report on status of research activities orally and through contribution to written reports.
- Synthesize and optimize chemical probes for potency and solubility.
- Calibrate, standardize, adjust, and maintain instruments.
- Collect and review data; analyze and interpret data and results.
- Gather, analyze, and interpret data; prepare summaries and reports.
- Operate and maintain analysis equipment.
- Order and maintain inventory of laboratory supplies; interact with sales representatives; obtain samples of research materials.
- Work with staff to obtain and organize radioactive samples for radio analysis.
- Acquire and implement knowledge of procedures for working with short-lived radioisotopes, gamma metrology and cyclotron produced radioisotope technology, and regulations for use and handling of radioactive materials.
- Carry out techniques to complete project goals; apply the appropriate methods to assist in solving operational problems; participate in planning specific experiments.
- Work with staff to develop experimental procedures and research protocols; carry out experiments as assigned.
- Maintain rodent colony breeding.
- Perform a variety of biochemical techniques and advanced analysis to complete studies with biological fluids and tissues of multiple origins, including rodent surgery and tissue dissection, analytical methods for radiotracer methodologies, in vitro receptor binging assays, and Radio-HPLC.
- Maintain computer database for various records.
- Maintain records for receipt and use of radioactive materials; carry out periodic lab surveys; dispose of radioactive and chemical waste according to Institutional and regulatory procedures.
- Interact internally with research staff, post-doctoral scholars, principal investigators, biological and radiation safety, and animal care.
- The contractor will respond to the Dept. of Radiation Safety for the annual inventory.
- The contractor will lead all the 3-H ligands in the lab.
- Ensure the lab is free of contamination.
- Formulate chemistry plans for the development of soluble, potent, selective small molecule probes of biological function.
- Perform chemical synthesis and optimization of small molecule probes for use in biological research.
- Perform experimental radiochemistry.
- Prepare reagents and maintain an active inventory of all chemicals kept in the laboratory.
- Perform analytical validation and testing of compositions and report results.
- Independently design, synthesize and optimize chemical probes for potency and solubility.
- Perform chemical and biochemical reactions and appropriate analytical analyses.
- Develop novel chemistry methodologies and technologies that advance the field and make recommendations.
- Train staff on new experiments, practices, operation and maintenance of instruments and equipment and safety practices.
- Work with staff to monitor and manage waste disposal.
- Identify the cause of common problems and mistakes and make necessary repairs.
- Develop novel chemistry methodologies and technologies that advance the field.
- Evaluate and implement. as warranted, new chemical technologies.
- Produce research reports and communicate results.
- Ph.D. in Chemistry
- At least 2 years of experience
- Experience with analytical chemistry technology, including HPLC, radio-HPLC and radioisotope experience
- MS Office
Dovel Technologies and its Family of Companies (Medical Science & Computing and Ace Info Solutions) was acquired in October 2021.
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