Scientist, Moderna Genomics, Animal Models and Pharmacology

Location
Cambridge, MA
Posted
Jul 02, 2022
Ref
R8546
Required Education
Doctorate/PHD/MD
Position Type
Full time

The Role:

As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. We are building an independent research and business unit for genomic medicines, called Moderna Genomics (mGx) based in Technology Square, Cambridge, MA. mGx will be an innovation engine for the company focused on discovering and delivering the next generation of in vivo gene editing and nonviral gene therapies. Moderna Genomics strives to be an industry leader in genomic medicines.

Moderna Genomics is seeking a skilled and highly motivated Scientist to contribute to a new, and rapidly growing program focused on advancing novel nucleic acid-based therapies.  The candidate will be part of the Animal Models and Pharmacology team. The Scientist will leverage their experience in in vivo pharmacology, ex vivo assay development and innate immunity to support and lead our novel drug modality and development. The successful candidate should have a strong background and understanding of in vivo pharmacology in mice/rats and ex vivo assay development and analysis of biological samples. Ideally, the candidate has experience in the analysis of immune responses to genomic therapeutics (i.e. viral vectors). Applicants should be collaborative team members, with excellent organizational and communication skills.

Here’s What You’ll Do:

  • Design, plan and execute in vivo studies involving intravenous, intramuscular, and subcutaneous delivery of nucleic acid-based therapies in mice and rats, in vivo imaging, necropsies and blood draws

  • Develop, implement and execute ex vivo assays (such as ELISA, Luminex, MSD, bDNA, qPCR, Western blot, JESS, Flow cytometry)

  • Scientifically develop and lead strategies to assess and target (innate) immune responses in vivo

  • Collaborate with internal teams to advance novel nucleic acid-based therapeutics

  • Deliver reproducible and impactful results under ambitious timelines

  • Analyze, interpret, and present data

  • Faithfully document scientific work

Here’s What You’ll Bring to the Table:

  • PhD (required) with 0-2 years of experience leading scientific in vivo projects in immunity, pharmacology or related subjects. Industry experience is a plus.

  • Strong scientific background in deciphering innate immune response in vivo

  • Proficient in pharmacology study planning and execution in mouse and rat (animal handling, dosing, sample collection)

  • Proficient in biochemical and molecular biology ex vivo assay development and execution (RT-qPCR, ELISA, Luminex, Western Blot, JESS, Flow cytometry)

  • Proficient in data analysis and visualization

  • Strong organizational skills, attention to detail, scientific versatility, flexibility, results-oriented

  • Excellent written, presentation and interpersonal communication skills; ability to collaborate across multiple teams is essential

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes 
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    •    Vacation, sick time and holidays
    •    Volunteer time to participate within your community
    •    Discretionary winter shut down 
    •    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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