AbbVie

Scientist I/II, In Vivo Pharmacology

Employer
AbbVie
Location
Lake County, Illinois
Posted
Jul 01, 2022
Ref
2208015
Required Education
Bachelors Degree
Position Type
Full time

Our expanding In Vivo Pharmacology group in Lake County, IL has an opening for a motivated in vivo pharmacologist who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics, with a focus on diseases of aging (including neurodegenerative, mitochondrial, and fibrotic disorders). Primary responsibilities include independently executing, reporting, and troubleshooting in vivo pharmacology studies based on previous hands-on experience and foundational theoretical knowledge.

The scientist will work on preclinical in vivo models for age-related diseases (e.g., fibrosis, immune, kidney, cardiovascular or CNS) as well as mechanism of action and PK/PD studies.

The position requires to interact with our in vitro biology, translational/ biomarkers, and medicinal chemistry teams to advance therapeutic agents through the R&D pipeline.

Responsibilities:

  • Acts as Study Leader/Coordinator for assigned studies and demonstrates proficiency in general in vivo procedures
  • Maintains competency in all aspects of rodent handling and treatment dosing of small molecules and biologics in mice and rats
  • Experience with ELISA / MSD methods and/or immunohistochemistry of paraffin/frozen sections is desired.
  • Develops and optimizes new methods/techniques to generate reliable and reproducible data in a timely manner. Experience in ex vivo processing of tissues (homogenization, RNA extraction) and analyses (ELISA, MSD, flow cytometry) is desired
  • Using an electronic notebook to maintain proprietary study records
  • Working closely with his/her supervisor to schedule and prioritize workload to manage several tasks simultaneously
  • Exhibiting excellent communication skills and the ability to present data clearly and thoroughly in both one-on-one interactions and group meetings

Position will be hired based on level of education and experience.

  • BS or MS in Pharmacology, Molecular Biology, Biochemistry, Physiology, or any related field of Biology required
  • Mnimum 5+ years of experience (BS) or 2+ years of experience (MS)
  • Proven expertise with design and execution of studies utilizing in vivo / ex vivo techniques in rodents is required
  • Experience with drug formulation and administration to rodents via SC, PO, IP, and IV routes
  • Experience utilizing in vivo / ex vivo techniques in rodents. This includes physiological measurements, tissue collection, and analysis by biochemical or histological methods. Experience with ELISA / MSD / Western Blots methods, flow cytometry and/or immunohistochemistry is desired
  • Strong problem-solving skills
  • Familiarity with data analysis, presentation, management and statistical software (e.g. Microsoft Office Suite, Prism) is necessary
  • Good communication skills and willingness to work with a cross-functional team of researchers is essential

Key Leadership Competencies

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the 'essence' and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.