Scientist - Therapeutics

Location
94080, South San Francisco
Posted
Jun 29, 2022
Required Education
Doctorate/PHD/MD
Position Type
Full time

Key Responsibilities:

  • Design and execute in vitro experiments, analyze and interpret data to support discovery and preclinical development using a variety of readouts
  • Work with a diverse and cross-functional team of wet-lab scientists and external collaborators to generate key datasets that are critical for the declaration of development candidates
  • Develop and validate PD biomarkers that can be applied both preclinically and clinically
  • Build and conduct validation assays to demonstrate proof-of-concept of a new platform in therapeutically relevant areas
  • Maintain accurate and complete documentation of experimental results for study reports and regulatory submissions

 

Qualifications:

  • Ph.D. in RNA biology, neurobiology, or oligonucleotide chemistry (or a relevant scientific discipline) with 2+ years experience in biotechnology and/or drug development
  • Experience in bioinformatics for genomics, NGS, and a programming language (R, Python) is preferred
  • Extensive knowledge of and experience with pharmacology, PK-PD relationships, and interrogating molecular target engagement and downstream physiological endpoints
  • Familiarity with cellular assays (e.g., cell lines, primary cells, neurons, IPSCs)
  • Hands-on experience with molecular biology including qPCR, western blots, and plate-based immunoassays (e.g., ELISAs, MSD, Luminex)
  • Creativity and the ability to work and debate constructively within an interdisciplinary team to achieve technical success and corporate milestones
  • Strong experience in statistical analysis software (e.g., Graphpad Prism)
  • Familiarity with data capture, analysis, and visualization within an Electronic Lab Notebook
  • Results-oriented individual with exceptional organization, attention to detail, scientific versatility, flexibility, critical thinking, and communication skills
  • Experience in a managerial role is preferred