Scientist, RNA Molecular Biology - Antisense Platform

South San Francisco, CA
Jun 29, 2022
Required Education
Position Type
Full time

Scientist, RNA Molecular Biology, Antisense Platform – Menlo Park, CA

About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. We provide affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Founded in 2017 and privately funded by visionary investors, we are headquartered in Waltham, MA with European labs in Cambridge, UK, and expanding to San Francisco Bay Area. As a reflection of our relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team, we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.


Who You Are

We are seeking two hard-working and detail-oriented bench Scientists to advance our novel antisense platform to create precision medicines. We are looking for people with expertise in RNA/DNA molecular biology and various biochemical, molecular, and cellular assays. This is a unique opportunity to be part of an experienced and talented team advancing novel antisense chemistry modalities for therapeutics. We hope to hear from you!


Principal Responsibilities

  • Learn and contribute to advancing novel antisense chemistry platform for therapeutics
  • Conceive hypothesis-driven experiments to systematically evaluate novel antisense chemistry in terms of biochemical and physical property characterization, in vitro and in vivo efficacy
  • Investigate the mechanisms of novel antisense modalities and examine their effects on targeted gene expression, and any off-target analysis
  • Characterize intracellular trafficking pathways, including endosomal escape, and their effects on antisense activity, internalization, and subcellular localization
  • Evaluate various drug delivery routes and dosing regimens, in terms of efficacy, biodistribution, and safety
  • Work closely with senior leadership to communicate findings and implications and help drive the development of the novel antisense platform for therapeutics
  • Collaborate with the business development team to build data packages
  • Be generous when others are needy, greedy or fearful


Required Qualifications and Skills

  • PhD in Molecular Biology, Cell Biology, Biochemistry, or equivalent
  • Title will be aligned with experience
  • Relevant experience in molecular biology, RNA translation including splicing, and/or gene editing
  • Hands-on experience with commonly used techniques in cell, molecular biology, and biochemistry – such as cell culture, transfection, CRISPR KO, stable cell line selection, DNA/RNA/Protein extraction and analysis, cloning, qRT-PCR, real-time PCR, subcellular fractionation, ELISA, Western blot, Northern blot, immunoprecipitation, immunofluorescence staining, and microscopy imaging
  • Ability to conduct data analysis, interpret experimental results, and independently draw conclusions
  • Strategic thinking skills, with a high degree of independence, self-motivation, and attention to detail
  • Ability to manage multiple assignments effectively in a quickly evolving environment
  • Excellent organizational and time management skills
  • An independent sense of urgency, persistence, and integrity
  • Excellent oral and written communication skills
  • Ability to work both independently and within a team
  • Ability to work well with external CROs and collaborators

Preferred Qualifications and Skills

  • Industry experience
  • Exposure to nucleic acid modalities, including siRNA, antisense, mRNA technology
  • Experience in RNA translation including splicing
  • Affinity to utilize new technologies and robotic automation for systematic consistency and efficiency
  • Experience in dosing rodents in various routes such as IV, IP, ICV, SC and harvesting organs for biochemical analysis
  • Hands-on experience in biodistribution studies


Benefits Include 

  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement and mentorship inside Alloy, through our venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental, and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through an individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others