Senior Scientist, Pharmacology

About BridgeBio Oncology Therapeutics & BridgeBio Pharma

BridgeBio Oncology Therapeutics (“BBOT”) is our team of researchers working to develop novel therapeutics to address dire unmet needs in oncology. Led by top scientists with extensive track records in drug development, like Frank McCormick and Eli Wallace, our team utilizes structure-based drug discovery techniques to target some of oncology’s most challenging and validated molecular targets, including KRAS and PI3Kα. We are focused and committed to patients, scientific excellence, and operational agility, and we understand that every minute counts in our efforts to develop new therapies to transform the lives of people living with cancer. Our main oncology laboratory is located in South San Francisco, though our research collaborators span the country and globe.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Who You Are

The Oncology Therapeutics team is hiring an exceptional and motivated Senior Scientist to contribute to collaborative teams focused on discovering and developing novel targeted small molecule oncology therapeutics.  The successful candidate will collaborate with team members to lead and conduct in vivo pharmacology oncology research studies.  We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team. 

Responsibilities

• Drive and implement the pharmacology strategy for cross-functional program teams developing small molecule therapeutics for oncology indications as a program pharmacology lead
• Design, plan, and execute in vivo (model development, tolerability, PK/PD, and efficacy) and ex vivo (target and mechanism engagement) pharmacology studies to assess the inhibition or activation of oncology targets with novel small molecule therapeutics 
• Manage one or two junior pharmacology team members
• Effectively document study details, analyze and interpret data, and clearly communicate results across the organization 
• Provide strategic and technical leadership to junior pharmacology team members 
• Manage studies at CROs 
No matter your role at BridgeBio, successful team members are:


• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• A highly motivated, committed individual with good organizational skills and a demonstrated commitment to quality, attention to detail, and team player mentality 
• Ph.D. in a biology-related discipline 
• Minimum Ph.D. and a minimum of 3 years of industry experience 
• Hands-on experience in a vivarium in an oncology setting required 
• Experience with oncology cell line-derived xenograft and syngeneic in vivo models: cell implantation, tumor measurements, dosing (e.g., IV, PO, SC, IP), and blood sampling 
• Experience with mammalian cell culture, test article formulation, protein expression quantification (ELISA, MSD, HTRF, FACS, westerns, IHC), and qPCR 
• Experience in managing research associate level personnel
• Experience managing CROs to deliver high-quality data in a timely manner is desirable
• Industry experience is highly preferred 
• Strong written and oral communication skills 
• Embraces the BridgeBio core values:  1. put patients first; 2. think independently, 3. be radically transparent; 4. every minute counts; and 5. let the science speak  

What We Offer

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.