Research Scientist, Fibrosis Biology
Gilead seeks a highly motivated and collaborative scientist to drive research efforts to discover and develop novel therapies for the treatment of inflammatory and fibrotic diseases, including fibrotic liver (NASH, PSC) and lung (IPF/ILD) and autoimmune (RA, lupus) diseases. The successful candidate will support discovery and translational research activities aimed at characterizing novel therapeutic targets and advancing discovery programs to the clinic. The role is within an established group focused on fibrotic, metabolic and inflammatory diseases and will interface with multidisciplinary project teams. This position provides an exciting opportunity to have high impact on the growth of a therapeutic area within an established research group focused on developing drugs for diseases with serious, unmet medical needs.
Essential Duties and Responsibilities:
The successful candidate will work in a project team-based research structure to lead or support biological investigations of new and established projects. Responsibilities include:
- Independently design, conduct and analyze experiments to support the initiation and/or advancement of drug candidates.
- Design, execute and analyze key in vivo pharmacology experiments to validate potential therapeutic targets, and lead early research to advance biology of novel targets/pathways
- Successful candidate must be able to manage multiple projects at any given time, and work in a fast-paced, cross-functional and highly collaborative team environment.
- Presents research findings and recommendations to senior staff, prepare research reports and peer-reviewed manuscripts, and contribute to the preparation of INDs, and patent filings.
- May manage and train Research Associates in design, initiation, and execution of laboratory experimentation with a "lead from the bench" approach:
- Work closely with academic collaborators and outside entities to advance research needs
- Demonstrates strong communication skills (both verbal and written) and interpersonal skills to communicate ideas, objectives and results.
Knowledge, Experience and Skills:
- PhD with 0-2+ years of industry experience and track record of success in academia
- Must have In vivo pharmacology experience with small rodents (mice and/or rat) experience with different routes of dosing (e.g. PO, SC, TV, IP), necropsy, tissue collection, non-invasive biofluid collection) and survival surgery (preferred).
- Experience performing multi-color FACS/Flow Cytometry from tissue and circulation required
- Experience in immunology, autoimmunity, inflammatory disease research required.
- Understanding of Fibrosis mechanisms and research preferred
- Experience with modern molecular biology techniques (e.g. ELISA, qPCR) ideal
- Prior experience in single-cell and single-nuclear RNA-Seq is a plus
- Strong analytical and computer skills are required, including proficiency with basic data analysis programs (Excel, GraphPad Prism) and application of statistics.
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