Sr/Director Translational Biology

San Francisco, California
Jun 25, 2022
Science/R&D, Biology
Biotech Bay
Required Education
Position Type
Full time

Olema Oncology (NASDAQ: OLMA) is a biopharmaceutical company developing innovative targeted therapies for women’s cancers.  Our lead program, OP-1250, a potential best-in-class complete estrogen receptor antagonist (CERAN), is in development to treat estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Olema recently initiated a Phase 1/2 dose-escalation and expansion clinical trial of OP-1250. We are supported in our mission by experienced and accomplished scientists and board members, leading healthcare investors, and some of the most innovative pharma companies. For more information about the company please visit

The Role:

Olema seeks a strong leader to oversee our translational biology efforts and to provide strategic and technical expertise for our research portfolio. You will be an integral part of the research leadership team, working cross functionally to drive our oncology drug discovery efforts. You will have the opportunity to design and oversee the execution of experiments with key collaborators and outside contract research organizations. You will work with all levels of our organization to advance our drug discovery efforts and to bring new small molecule drugs to patients.

This is a fantastic opportunity for a talented scientist to join a company with an industry leading Management team and Board of Directors and build an innovative women’s oncology company with significant potential to transform breast cancer treatments.  

What You Will Do:
  • Provide strategic, scientific, and managerial leadership to build and drive translational biology efforts
  • Oversee identification and exploration of drug targets and design strategies for target validation and preclinical development
  • Develop biomarker strategies to enable progression from preclinical to clinical studies in collaboration with colleagues in research and clinical development departments
  • Lead multidisciplinary drug discovery project teams in a fast-paced, results-driven biotech environment
  • Collaborate with data science and clinical teams to develop combination strategies for oncology indications
  • Manage relationships with external thought leaders aimed at gaining better understanding of target biology, pharmacodynamic markers, and patient selection and stratification

What You Will Bring:

  • Ph.D. with 10+ years of experience in biology, with 7+ years in biotech/pharmaceutical industry
  • Minimum of 3 years direct leadership experience
  • Experience leading translational biology efforts on project teams at various stages of the programs
  • Strong understanding of cancer cell signaling pathways and experience with PK/PD/efficacy studies to validate disease indications
  • A strong track record of success in translating biological findings to development candidate molecules
  • Experience with small molecule drug development and IND submissions
  • Experience with selection and development of in vivo disease models
  • Experience with cancer genomics/genetics databases and data analysis
  • Experience with building and managing effective teams
  • Experience managing external partners
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment

Personal Characteristics:

Given the “small biotech” nature of the Company, cultural fit of the successful candidate is an important criterion for their success at Olema. Desired characteristics include a high level of curiosity, intelligence, ability to work independently, “can do” attitude, and ability to work cross-functionally. Strong initiative and follow through are essential for this job.

Specific personal characteristics include:

  • Excellent verbal and written communication and skills coupled with the ability to advocate for a position and engage in vigorous debate to reach the best decision
  • Analytical thinking with problem-solving skills and the ability to adapt to changing priorities and deadline
  • A commitment to excellence
  • Self-motivated and enthusiastic; fast learner who can identify the core project challenges and expeditiously change course as required in a fast-paced organization
  • Teamwork and collaboration; balances team and individual responsibilities; gives and welcomes feedback; puts success of team above own interests; supports everyone's efforts to succeed; shares expertise with others
  • A demonstrated ability to make decisions on incomplete information and in areas where a high degree of professional judgment is required
  • Be a “difference maker” in terms of one’s professionalism and contributions
  • Have impeccable professional ethics, integrity and judgment
  • Be collegial, hard-working, confident, a self-starter and have a passion for results
Additional Information:   We require all employees to be fully vaccinated against COVID-19, subject to approved medical or religious exemptions or disability accommodations.   We believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated. We provide equal opportunity to all employees and applicants for employment.    Olema offers competitive compensation and benefits. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with a platform to develop their long-term careers.   Please note: Olema does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.