Research Associate, ex vivo Pharmacology

About IDEAYA Biosciences:
IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage synthetic lethality-focused precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.
IDEAYA recently announced a landmark strategic partnership with GSK in Synthetic Lethality for certain pipeline programs. The GSK partnership is transformative and enables IDEAYA and GSK to collectively build an industry leading platform and pipeline in Synthetic Lethality. For more information, please see www.ideayabio.com.

Position Summary
IDEAYA is seeking a South San Francisco based Senior Research Associate for our Pharmacology and Toxicology group.  This individual will play a key role in the development and execution of preclinical models to understand the efficacy and PK/PD relationships of our small molecule agents under development for the treatment of cancer.  The ideal candidate will enjoy working with multi-disciplinary teams in a fast-paced environment and will have the passion to contribute to the discovery and development of novel therapeutic agents for cancer patients.

What you'll do:

• Play a key role in evaluating mechanistic hypotheses for drug responses using samples generated from in-vivo studies, utilizing diverse molecular biology techniques to assess gene modulation and interrogate pathways of interest
• Lead the development and implementation of ex-vivo assays for screening new potential therapeutics in vivo.
• Contribute to method development for new ex-vivo assays, experimental protocols, and related readouts for specific project needs.
• Collaborate with research teams on relevant ex vivo assays (Flow cytometry, qPCR, MSD, IHC, etc.)
• Design and manage research experiments, and analyze and interpret scientific data under general supervision
• Present data and report on project status at team, intra- and inter-departmental research meetings
• Document all laboratory activities, protocols, analysis methods and the collection of data

Requirements:

• BA/BS or MS with 1+ years’ (Research Associate) or 3+ years’ (Senior Research Associate) laboratory experience in cancer biology, biochemistry, immunology or related field
• Experience in mammalian tissue culture and ex vivo assays such aswestern blot, ELISA, gene expression analysis (qRT-PCR), flow cytometry, MSD, IF, and IHC.
• Practical laboratory experience handling and processing of animal tissues for DNA, RNA, and protein extraction.  
• Experience in assay development, optimization and troubleshooting is a plus
• Ability to effectively design, plan, execute, and analyze experiments under general supervision.
• Efficient time management and the ability to adapt to shifting priorities and timelines
• Strong interpersonal skills and effective communication with cross function team members

The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite at the Company’s facilities and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization.

Benefits
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

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