Software Engineer, Bioinformatics - #2415

Menlo Park, CA
Jun 17, 2022
Required Education
Bachelors Degree
Position Type
Full time
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit

The Senior Bioinformatics Engineer will be part of a cross functional team that collectively develops the bioinformatics data processing tools that are run as core components of Grail’s diagnostic test. In this role, you will work to improve our understanding of cancer signal and noise from sequencing data, translate these findings into algorithmic approaches, and write well-written, scalable, and robust software for bioinformatics sample processing pipelines. 

An ideal candidate will have a background in pioneering new methodologies and developing tools for processing high volumes of data in a production environment. A deep understanding of existing bioinformatics algorithms for handling genetics data is a plus. 
You Will:
  • Develop new bioinformatics approaches for analysis of large-scale genomics datasets and application development in a fast paced research environment.
  • Collaborate and coordinate activities with multiple internal teams including software, clinical, operations, research, and product development.
  • End-to-end analysis that includes design, data gathering, processing, analysis, iteration with stakeholders, and presentation of results.
  • Practice sound engineering principles, iterative approach to software design and adherence to rigorous, high-quality, testable code development.
  • Development of common tools, libraries and infrastructure to assist in scaling bioinformatics research efforts.
  • Take initiative to fix issues as they come up, ensure robustness of all product code, and pioneer new initiatives to improve results.

Your Background Should Include:
  • BS/MS/PhD in a quantitative scientific field (computer science, engineering, mathematics, statistics, bioinformatics, etc.)
  • 2+ years of industry experience.
  • Experience with R or Python programming and at least one system-level programming language like Go, Java or C++.
  • Experience with AWS, GCP, or Azure.
  • Experience with a workflow engine, like Reflow or NextFlow a plus.
  • Experience with cross-functional collaboration while ensuring data quality and commitment to analysis reproducibility.
  • Experience with real-time data visualization and analytics tools.
  • Experience with next-generation sequencing data is a plus.
  • Excellent interpersonal communication (written and verbal) and organizational skills.
  • Excellent team player with a demonstrated track record of success in a cross-functional team environment.
  • Consistent commitment to delivering on team goals with a sense of shared urgency.

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, GRAIL has made the decision to require all U.S. employees receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.