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Pharmacologist

Employer
Alkahest, Inc.
Location
San Carlos, California
Start date
Jun 15, 2022

Job Details

We are seeking a pharmacology expert to lead the company's pharmacology activities, including clinical pharmacology and pharmacometrics.

Summary & Scope of Position:

The Pharmacologist will be responsible for overseeing the pharmacometric strategy relating to the pre-clinical and clinical aspects of our development programs. 

Primary Responsibilities:

  • Establish pharmacology and pharmacometrics strategy to support Alkahest pre-clinical and clinical development programs
  • Accountable for human dose projection and dose selection
  • Partner with matrixed nonclinical and clinical team on study design and protocol, and data analysis
  • Leverage external resources, as needed, to optimize dosing strategy and PK/PD insights
  • Perform PK and PK/PD analyses using various tools and approaches. 
  • Serve as the Pharmacology expert across study and program teams 
  • Contributes to Clinical Pharmacology sections of regulatory documents 
  • Collaborate and liaise with Nonclinical Pharmacology colleagues to support overall programmatic pharmacology and translational PK/PD strategy
  • Team player with good oral and written communication skills

Requirements:

  • A PharmD or PhD in Pharmacology or similar with 5+ years of experience in the CRO, pharmaceutical or biotech industry
  • Extensive knowledge and demonstrated experience in clinical pharmacology and pharmacometrics throughout the drug discovery process
  • Knowledge and hands-on experience in modeling and simulation 
  • Proficiency in application of quantitative PK/PD software
  • Collaborative and flexible in personal interactions
  • Ability to work proactively and effectively, with exceptional problem-solving skills

If you have the work ethic and mental agility to embrace a fast-paced and rapidly evolving environment, you will be rewarded with diverse and exciting experiences. This is your chance to add real value to an entrepreneurial organization that supports bold innovation and new ideas. Alkahest welcomes passionate, team-oriented colleagues who are looking to improve the health of patients worldwide by developing a deeper understanding of age-related disease.

Applicants and new hires are subject to the Company’s Mandatory Vaccination Policy.

Company

At Alkahest, we strive to lead the way towards effective therapies for patients suffering from diseases associated with the detrimental processes of aging. We believe that as an industry, we simply haven’t done enough to help drive solutions for the most under-treated and devastating diseases affecting this growing demographic. We want to help.

Aging is the dominant risk factor in degenerative diseases. Many of the pressing age-related and neurodegenerative diseases have a profound impact on patients and their caregivers, yet have very limited treatment options. Alkahest has embarked upon a simple but elegant approach to treat disorders of aging by capitalizing on the body’s own natural regulatory and communication mechanisms, leveraging the plasma proteome. The promise of this science, and the potential to make a difference to patients around the world, was the founding principle of Alkahest.

For all of the great progress we have made so far, we credit our dedicated and impassioned team for driving our successes. Our culture is warm and supportive, genuine and ethical, rigorous and scientific, and collaborative yet entrepreneurial. Based in Silicon Valley, home to many leaders in the biotechnology industry, the heart of our culture is scientific innovation. We work hard, yet we have fun while we’re doing so. We are passionate about both our collegial atmosphere as well as working together on cutting-edge therapies that will change the lives of patients. We know we have a lot further to go, and we’re ready for the long haul.

Company info
Website
Phone
650-801-0474
Location
75 Shoreway Road, Suite D
San Carlos
California
94070
US

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