Scientist / Sr. Scientist, Medicinal Chemistry

South San Francisco, California
Highly competitive with excellent benefits and 401k
Jun 14, 2022
Required Education
Position Type
Full time

About SiteOne

SiteOne Therapeutics is a clinical-stage biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as acute and chronic pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are exquisitely selective inhibitors of voltage-gated sodium ion channels that are under investigation by systemic and local routes of administration. SiteOne recently announced a collaboration and license agreement with Vertex to advance non-opioid therapeutics for the treatment of pain. The company is headquartered in South San Francisco, CA with additional capabilities in Bozeman, MT. An opportunity is currently available for a talented and highly motivated scientist to join the medicinal chemistry team in South San Francisco (On-site).


  • Design, synthesize and characterize novel small molecule drug candidates
  • Closely follow and integrate the results of biological and ADME characterization into lead optimization strategies
  • Perform experiments to define new chemical routes to compounds, scaffolds and intermediates of interest
  • Manage and supervise external chemistry FTEs and other discovery resources
  • Provide regular progress updates to chemistry and cross-functional project teams
  • Stay abreast of the scientific literature and closely monitor the competitive patent landscape
  • Contribute to the preparation of technical documents including patent applications and publications


  • A MS, PhD or equivalent degree with a focus on organic or medicinal chemistry
  • Expertise in complex, multi-step organic synthesis and/or reaction methodology development
  • Excellent analytical and problem solving skills, with the ability to rapidly integrate emerging biological, ADME and other lead profiling data into compound design strategy
  • Up to 7 years of relevant post-degree work experience
  • A track record, as demonstrated by publications and/or patent applications, that shows technical proficiency, scientific creativity, teamwork, organizational and interpersonal skills
  • A deep commitment to scientific integrity, and mission-driven focus on the discovery and development of transformative medicines for the benefit of patients