Scientist / Sr. Scientist, Medicinal Chemistry
- Employer
- SiteOne Therapeutics
- Location
- South San Francisco, California
- Salary
- Highly competitive with excellent benefits and 401k
- Start date
- Jun 14, 2022
View more
- Discipline
- Science/R&D, Chemistry, Neuroscience
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
Job Details
About SiteOne
SiteOne Therapeutics is a clinical-stage biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as acute and chronic pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are exquisitely selective inhibitors of voltage-gated sodium ion channels that are under investigation by systemic and local routes of administration. SiteOne recently announced a collaboration and license agreement with Vertex to advance non-opioid therapeutics for the treatment of pain. The company is headquartered in South San Francisco, CA with additional capabilities in Bozeman, MT. An opportunity is currently available for a talented and highly motivated scientist to join the medicinal chemistry team in South San Francisco (On-site).
Responsibilities
- Design, synthesize and characterize novel small molecule drug candidates
- Closely follow and integrate the results of biological and ADME characterization into lead optimization strategies
- Perform experiments to define new chemical routes to compounds, scaffolds and intermediates of interest
- Manage and supervise external chemistry FTEs and other discovery resources
- Provide regular progress updates to chemistry and cross-functional project teams
- Stay abreast of the scientific literature and closely monitor the competitive patent landscape
- Contribute to the preparation of technical documents including patent applications and publications
Requirements
- A MS, PhD or equivalent degree with a focus on organic or medicinal chemistry
- Expertise in complex, multi-step organic synthesis and/or reaction methodology development
- Excellent analytical and problem solving skills, with the ability to rapidly integrate emerging biological, ADME and other lead profiling data into compound design strategy
- Up to 7 years of relevant post-degree work experience
- A track record, as demonstrated by publications and/or patent applications, that shows technical proficiency, scientific creativity, teamwork, organizational and interpersonal skills
- A deep commitment to scientific integrity, and mission-driven focus on the discovery and development of transformative medicines for the benefit of patients
Company
SiteOne Therapeutics, headquartered in Bozeman, Montana with a research team in San Francisco, California, is dedicated to developing novel pain therapeutics to safely, effectively and efficiently treat acute and chronic pain without the limitations of existing drugs, such as opioids. The company’s therapeutic candidates are highly selective sodium ion channel 1.7 (NaV1.7) inhibitors based on naturally occurring small molecules. Given the critical role that NaV1.7 plays in the generation and conduction of pain signals, combined with the urgent need for new, non-opioid pain therapies, SiteOne is focused on advancing its lead products to serve patients that suffer from moderate to severe pain.
YEAR FOUNDED:
2010
LEADERSHIP:
Founders: Sandip Biswal, Justin Du Bois, David Yeomans, John Mulcahy, and George Milijanich
Founder and CSO: George Miljanich
CEO: Stan E. Abel
- Website
- http://siteonetherapeutics.com/
- Phone
- 4064614618
- Location
-
203 Enterprise Boulevard
Suite 3
Bozeman
Montana
59718
US
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