Senior Principal Scientist of In Vivo Oncology

New York, NY
Jun 12, 2022
Pharm Country
Required Education
Position Type
Full time

We are looking to hire a Senior Principal Scientist of In Vivo Oncology to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods. We are seeking outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery programs and collaborations. 

Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Ten of the programs we have worked on have progressed into preclinical development with four currently in clinical trials and one approved by the FDA. 

The successful candidate will have a track record of innovative and collaborative research, demonstrated through project milestone delivery and peer-reviewed publications. The successful candidate is expected to be involved in significant interaction and collaboration within the company and with external KOLs/partners/CROs to provide support on translational biology activities and guide project transition from preclinical drug discovery towards clinical development for advanced oncology programs.


  • Lead the biology and pharmacology for oncology small molecule discovery programs in close collaboration with cross functional discovery teams
  • Guide research strategies and experimentation with a focus on in vivo pharmacology, translational oncology models and biomarker discovery. Drive pharmacology execution with CRO partners
  • Provide scientific leadership in the area of oncology, including identification of therapeutic target opportunities that are a fit for Schrödinger’s proprietary computational platform
  • Stay informed on trends and emerging themes regarding research and development in the oncology field e.g. by interacting with KOLs and participating in scientific meetings
  • Collaborate with translational and clinical sciences colleagues to define and validate preclinical and clinical biomarkers, indication selection and overall translational strategy
  • Support IND submission for candidate molecules advancing from preclinical to clinical setting

Essential Qualifications and Experience:

  • Ph.D. in cancer biology or related field with 5+ years industry oncology drug discovery experience, and proven success leading an in vivo pharmacology effort with creative approaches to problem solving, preferable in small molecule drug discovery.
  • In-depth knowledge/understanding of cancer pathways, cellular and animal models across solid tumor and/or hematologic malignancies, as well as various mechanisms of therapeutic response, resistance and drug combination strategy.
  • Experience in the identification and validation of translational biomarkers in support of drug development programs  
  • Experience in managing external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines
  • Demonstrated success as a lead biologist advancing novel scientific discoveries through discovery and supporting mechanism of action insights in drug discovery and/or clinical development
  • Outstanding presentation and communication skills
  • Skilled at working in a multidisciplinary environment

Additional Skills:

  • Proven record of innovative thinking to propose and champion new ideas and solve problems
  • Comfortable working across a number of oncology areas and able to shift gears quickly
  • Must be open to change and the unknown with a creative and resourceful nature; a self-starter, proactive and results-oriented with high performance standards

Pay and perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work for the past three years running.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.