Senior Scientist--Analytical Assay Development, Vaccines
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.What You Will Achieve
This is a laboratory-based position within the Vaccine Research and Development – Analytical Development group. The candidate will lead a small team to develop robust analytical assays to screen, pool and qualify polyclonal antibody reagents for use in bioassays required for release and stability of glycoconjugate based vaccines. Assays include but are not limited to Enzyme-Linked Immunosorbent Assays (ELISAs), nephelometry and MSD. In addition, the candidate will provide analytical support for bioprocess and formulation development by performing routine and non-routine sample testing.How You Will Achieve It
Lead and directly manage a small team of scientists to execute project goals.
Provide lab-based assay development support for screening, pooling and qualifying polyclonal antibody reagents by ELISA, nephelometry or MSD.
Effectively use ICH guidelines for method and reagent qualification to design, plan, and execute assay development, qualification and transfer studies with a high degree of independence.
Analyze data using appropriate statistics, where needed.
Provide sample testing support for process development, formulation development, critical reagent characterization and for on-going stability studies.
Document experiments, analyze data, and provide conclusions obtained from assay development and sample testing experiments contemporaneously in either an electronic or paper notebook as directed.
Author technical documents including, development reports, analytical test methods, and method qualification reports.
Read scientific and technical literature to stay current in the field and to bring new and improved technologies to the laboratory. Provide daily laboratory operations support.
PhD degree in Biological Science, Biochemistry or related discipline with a minimum of 2 years related experience working in a lab independently or an MS plus a minimum of 5 years of related experience working in a lab independently is required.
Experience with biochemical and immunological techniques and qualification using ICH guidelines is essential.
Experience in vaccine analytical assay development is essential.
Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is required.
Strong verbal and written communication skills
Experience with rabbit immunizations or polyclonal antibody generation
Experience developing antibody binding assays. ie ELISA, nephelometry and MSD.
Experience leading/managing a small team.
Experience with documentation of laboratory notebook in an electronic format.
Standard laboratory conditions – sitting, standing, primarily lab based
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
40 hours per week.
OTHER JOB DETAILS
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.Research and Development